1,2-diphenyl-imidazolidine | 42163-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,2-diphenyl-imidazolidine
• 英文别名: Diphenylimid azolidin；1,2-diphenylimidazolidine
• CAS: 42163-92-8
• 化学式: C₁₅H₁₆N₂
• 分子量: 224.305
• InChiKey: LDJFOZIAFPUDOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR PRODUCING CARBOXYLIC ACID ESTER<br/>[FR] PROCÉDÉ DE PRODUCTION D'ESTER D'ACIDE CARBOXYLIQUE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2012026617A1

  公开（公告）日：2012-03-01

  The present invention relates to a process for producing a carboxylic acid ester, comprising a step of oxidizing an aldehyde by mixing an alcohol, carbon dioxide, the aldehyde and at least one compound selected from the group consisting of compounds represented by the formulae (2-1) and (2-2): wherein R2 represents an alkyl group optionally having a substituent or the like; R3 and R4 each independently represents an alkyl group optionally having a substituent or the like or R3 and R4 are linked together to form a divalent hydrocarbon group optionally having a substituent or the like; Y represents a group of -S- or a group of -N(R5)-, wherein R5 represents an alkyl group optionally having a substituent or the like, or R5 is linked to R4 to form a divalent hydrocarbon group optionally having a substituent; and R8 represents an alkyl group.

  本发明涉及一种生产羧酸酯的方法，包括通过混合醇、二氧化碳、醛和来自由式（2-1）和（2-2）所代表的化合物组成的群体中至少选取一种化合物，氧化醛的步骤：其中R2代表可能具有取代基等的烷基基团；R3和R4各自独立地代表可能具有取代基等的烷基基团，或者R3和R4连接在一起形成可能具有取代基等的二价碳氢基团；Y代表一个-S-基团或一个-N(R5)-基团，其中R5代表可能具有取代基等的烷基基团，或者R5连接到R4形成可能具有取代基的二价碳氢基团；R8代表一个烷基基团。
• [EN] PROCESS FOR PRODUCING ALPHA-HYDROXYKETONE COMPOUND<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN COMPOSÉ D'ALPHA-HYDROXYCÉTONE
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2010041767A1

  公开（公告）日：2010-04-15

  A process for producing an α-hydroxyketone compound, which comprises subjecting an aldehyde compound to a coupling reaction in the presence of an alkoxyimidazolidine compound represented by the formula (1) wherein Rｿ1? and Rｿ2? independently represent a hydrogen atom, etc., Rｿ3? and Rｿ4? independently represent a substituted or unsubstituted aryl group, etc. and Rｿ5? represents an alkyl group.

  一种生产α-羟基酮化合物的方法，包括在式（1）所表示的烷氧基咪唑啉化合物的存在下，将醛化合物进行偶联反应，其中R1和R2分别独立表示氢原子等，R3和R4分别独立表示取代或未取代的芳基等，而R5表示烷基。
• Backbone-modified oligonucleotide analogs and methods for using same
  申请人：——

  公开号：US20020183502A1

  公开（公告）日：2002-12-05

  Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.

  本发明提供了具有改良核酸酶抵抗性和改良细胞摄取能力的治疗性寡核苷酸类似物。通过用四原子连接基取代野生型寡聚物中发现的磷酸二酯间糖连接，形成独特的二核苷酸和多核苷酸，可用于调节RNA表达和治疗。还公开了合成和使用的方法。
• Backbone modified oligonucleotide analogues
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US20030045705A1

  公开（公告）日：2003-03-06

  Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.

  提供了具有改进核酸酶抗性和改进细胞摄取能力的治疗性寡核苷酸类似物。通过用四原子连接基取代自然寡聚体中发现的正常磷酸二酯间糖链，形成独特的二核苷酸和多核苷酸，可用于调节RNA表达和治疗。还公开了合成和使用的方法。
• EP0544757A4
  申请人：——

  公开号：EP0544757A4

  公开（公告）日：1994-07-06