N-((2-chlorophenyl)(phenyl)methyl)benzamide | 851-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((2-chlorophenyl)(phenyl)methyl)benzamide
• 英文别名: N-Benzoyl-2-chlor-benzhydrylamin；N-[(2-chlorophenyl)-phenylmethyl]benzamide
• CAS: 851-64-9
• 化学式: C₂₀H₁₆ClNO
• 分子量: 321.806
• InChiKey: YRIRXPJFDMPIDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯二苯甲酮 在 sodium hydroxide 作用下， 反应 10.0h， 生成 N-((2-chlorophenyl)(phenyl)methyl)benzamide
  参考文献：
  名称：

  ROSSI; PIROLA; GROPPETTI, Farmaco, Edizione Scientifica, 1965, vol. 20, p. 25 - 35

  摘要：

  DOI：

文献信息

• A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides
  作者：Tamara Beisel、Georg Manolikakes

  DOI：10.1021/ol402949t

  日期：2013.12.6

  A Lewis acid palladium-catalyzed reaction of amides, aryl aldehydes, and arylboronic acids is described. This new method allows for a practical and general synthesis of α-substituted amides from simple, readily available building blocks.

  描述了路易斯酸钯催化的酰胺，芳基醛和芳基硼酸的反应。该新方法允许从简单，容易获得的结构单元实际和通用地合成α-取代的酰胺。
• A palladium-catalyzed arylation of N-acyl-N,O-acetals with arylboronic reagents: synthesis of diarylmethylamines protected by easily removable acyl group
  作者：Qian Chen、Chao Liu、Fang Guo、Liang Li

  DOI：10.1016/j.tet.2015.06.017

  日期：2015.8

  An efficient process was developed to synthesis diarylmethylamines protected by a readily removable acyl group using a palladium-catalyzed arylation of N-acyl-N,O-acetals with arylboronic reagents. The attractive features of this protocol are: the ease of preparing substrate and the mild reaction condition under an air atmosphere. Moderate enantioselectivity was observed in preliminary screening studies of chiral ligands. (C) 2015 Elsevier Ltd. All rights reserved.