JR2Upl7M5E | 2254541-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: JR2Upl7M5E
• 英文别名: 4-[4-[4-(4-cyanophenoxy)-2-formylphenyl]-3-formylphenoxy]benzonitrile
• CAS: 2254541-78-9
• 化学式: C₂₈H₁₆N₂O₄
• 分子量: 444.4
• InChiKey: CLWZNKOMAOYFIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• PROCESS FOR PREPARATION OF CRISABOROLE
  申请人：Glenmark Life Science Limited

  公开号：US20200172560A1

  公开（公告）日：2020-06-04

  The present invention relates to a process for the preparation of crisaborole, the process comprising reacting a compound of formula IIa with a compound of formula III to give a compound of formula IV and converting the compound of formula IV to crisaborole. The present invention also relates to a process for the preparation of crystalline crisaborole.