1-(2-chloro-phenyl)-3-(7(9)H-purin-6-yl)-urea | 35068-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-chloro-phenyl)-3-(7(9)H-purin-6-yl)-urea
• 英文别名: 1-(2-chlorophenyl)-3-(7H-purin-6-yl)urea
• CAS: 35068-00-9
• 化学式: C₁₂H₉ClN₆O
• 分子量: 288.696
• InChiKey: YVAODOLOKQSLHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Viral treatment system
  申请人：Prendergast, Patrick T.

  公开号：EP0355825A2

  公开（公告）日：1990-02-28

  This invention relates to pharmaceutical formulations of compounds and drugs for treatment against viruses and prions (proteinaceous infectious particles) eg. CMV, Herpes Simplex, Hepatitis B, Scapie Creutzfeldt-Jakob Disease, in particular for drug treatment of persons and animals suffering from certain retroviral infections, and of persons suffering from infection by retroviruses related to human immuno-deficiency viruses (HIV), and for prophylactic drug treatment of persons who may be suffering from such infections. The anti-viral pharmaceutical formulations according to the invention have the general formula:

  本发明涉及用于治疗病毒和朊病毒（蛋白质感染性颗粒）（如巨细胞病毒、单纯疱疹、乙型肝炎、斯卡皮-克雅氏病）的化合物和药物的药物制剂，特别是用于患有某些逆转录病毒感染的人和动物，以及患有与人类免疫缺陷病毒（HIV）有关的逆转录病毒感染的人的药物治疗，以及可能患有此类感染的人的预防性药物治疗。 根据本发明的抗病毒药物制剂具有通式：
• Use of particular compounds for manufacture of pharmaceutical formulations for treatment against various parasites, mycoplasmas, other indications and other infections
  申请人：Prendergast, Patrick Thomas

  公开号：EP0462621A2

  公开（公告）日：1991-12-27

  One or more compounds are used for the manufacture of a pharmaceutical formulation for treatment against one or more kinds of parasites and/or one or more diseases caused by such parasites, against one or more kind of Mycoplasma and/or one or more diseases caused by such Mycoplasmas and/or against one or more of the following indications or infections (a) hairy leukoplakia, (b) oral candidosis, (c) mouth ulcerations-aphthous/herpetic/bacterial, (d) fungal candida, (e) human papilloma virus, (f) molluscum contagiosum, (g) squamous oral carcinoma, (h) Kaposi's sarcoma oral lesions, (i) periodontitis, 0) necrotizing gingivitis, (k) orofacial herpes zoster, and (I) rotaviruses. The present invention furthermore provides specific formulations including such compound(s).

  一种或多种化合物用于制造药物制剂，以治疗一种或多种寄生虫和/或由此类寄生 虫引起的一种或多种疾病、一种或多种支原体和/或由此类支原体引起的一种或 多种疾病和/或下列一种或多种适应症或感染 (a) 毛状白斑病、(b) 口腔念珠菌病，(c) 口腔溃疡--疱疹/带状疱疹/细菌性，(d) 念珠菌真菌，(e) 人类乳头瘤病毒，(f) 传染性软疣，(g) 口腔鳞状上皮癌，(h) 卡波西肉瘤口腔病变，(i) 牙周炎，0) 坏死性牙龈炎，(k) 口面部带状疱疹，以及 (I) 轮状病毒。本发明还提供了包括此类化合物的特定制剂。
• Combination therapy for reduction of toxicity of chemotherapeutic agents
  申请人：——

  公开号：US20020169140A1

  公开（公告）日：2002-11-14

  There are provided compositions, pharmaceutical formulations and kits for treating neoplasms and tumours, viral infections, bacterial infections, or parasite infections. There are also provided compositions, pharmaceutical formulations and kits for suppression of immune response rejection in tissue transplantation. Also provided are methods of treating such conditions.

  提供了用于治疗肿瘤、病毒感染、细菌感染或寄生虫感染的组合物、药物制剂和试剂盒。还提供了用于抑制组织移植中免疫反应排斥的组合物、药物制剂和试剂盒。还提供了治疗此类病症的方法。
• COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM
  申请人：Prendergast, Patrick T.

  公开号：EP2026810A2

  公开（公告）日：2009-02-25
• COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS
  申请人：Prendergast, Patrick T.

  公开号：EP2134347A2

  公开（公告）日：2009-12-23