(R)-methyl-2-methyl-2-(4,5-dihydro-4-isopropyl-2-thiazolyl)propanedithioate | 420133-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: (R)-methyl-2-methyl-2-(4,5-dihydro-4-isopropyl-2-thiazolyl)propanedithioate
• CAS: 420133-87-5
• 化学式: C₁₁H₁₉NS₃
• 分子量: 261.477
• InChiKey: GHZYKOFDDNQTQC-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.87
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-methyl-2-methyl-2-(4,5-dihydro-4-isopropyl-2-thiazolyl)propanedithioate 在 甲基磺酰氯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 48.17h， 生成 (R,R)-2,2'-(1-methylethylidene)bis[4,5-dihydro-4-isopropylthiazoline]
  参考文献：
  名称：

  Synthesis of new chiral thiazoline-containing ligands

  摘要：

  New chiral ligands. including bi- and tridentate thiazoline derivatives, analogues of known oxazolines, have been synthesized by it general and convenient procedure. starting from dithioesters and commercial enantiopure 2-aminoalcohols. A preliminary Lest shows the ability of such ligands to act as asymmetric catalysts in Pd-catalyzed allylic substitution reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00481-5
• 作为产物：
  描述：

  (R)-N-[1-(hydroxymethyl)-2-methylpropyl]-2-methylpropanethioamide 在 叔丁基锂 、 甲基磺酰氯 、 三乙胺 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 5.17h， 生成 (R)-methyl-2-methyl-2-(4,5-dihydro-4-isopropyl-2-thiazolyl)propanedithioate
  参考文献：
  名称：

  Synthesis of new chiral thiazoline-containing ligands

  摘要：

  New chiral ligands. including bi- and tridentate thiazoline derivatives, analogues of known oxazolines, have been synthesized by it general and convenient procedure. starting from dithioesters and commercial enantiopure 2-aminoalcohols. A preliminary Lest shows the ability of such ligands to act as asymmetric catalysts in Pd-catalyzed allylic substitution reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00481-5