3-[(4-Hydroxybutyl)amino]benzonitrile | 1249443-90-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(4-Hydroxybutyl)amino]benzonitrile
• 英文别名: 3-(4-hydroxybutylamino)benzonitrile
• CAS: 1249443-90-0
• 化学式: C₁₁H₁₄N₂O
• 分子量: 190.24
• InChiKey: SKIDGYGFSDNHLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  56
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 3-CYANOANILINOALKYLARYLPIPERAZINE DERIVATIVE AND USE THEREOF IN PREPARING DRUGS
  申请人：NHWA Pharma. Corporation

  公开号：US20150105399A1

  公开（公告）日：2015-04-16

  Disclosed in the present invention is a 3-cyanoanilinoalkylarylpiperazine derivatives and use thereof in preparing drugs; the 3-cyanoanilinoalkylarylpiperazine derivatives disclosed by the present invention has very useful pharmaceutical properties and good tolerance, especially the use as novel analgesic drugs, novel antidepressants, and novel analgesic and antidepressive drugs. This class of compounds are central analgesics regulating 5-hydroxytrptamine, and also are novel antidepressants regulating 5-hydroxytrptamine. This class of compounds also has less toxic and side effects and a higher safety range. The 3-cyanoanilinoalkylarylpiperazine derivative is a compound shown as formula (III) or free base or salt thereof:

  本发明公开了一种3-氰基苯胺烷基芳基哌嗪衍生物及其在制备药物中的应用；本发明公开的3-氰基苯胺烷基芳基哌嗪衍生物具有非常有用的药理特性和良好的耐受性，特别是作为新型镇痛药、新型抗抑郁药和新型镇痛抗抑郁药的用途。这类化合物是中枢镇痛剂，调节5-羟色胺，同时也是新型抗抑郁药，调节5-羟色胺。这类化合物还具有较小的毒性和副作用，安全范围更高。3-氰基苯胺烷基芳基哌嗪衍生物是一种化合物，其化学式为（III）或其游离碱或盐形式：
• US9238632B2
  申请人：——

  公开号：US9238632B2

  公开（公告）日：2016-01-19