2,2'-disulfanediyl-di-isonicotinic acid | 18616-06-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,2'-disulfanediyl-di-isonicotinic acid
• 英文别名: 2,2'-Disulfandiyl-di-isonicotinsaeure；Di-(4-Carboxy-pyridyl-(2))-disulfid；2-[(4-Carboxypyridin-2-yl)disulfanyl]pyridine-4-carboxylic acid
• CAS: 18616-06-3
• 化学式: C₁₂H₈N₂O₄S₂
• 分子量: 308.339
• InChiKey: KTWIATYFXLGCQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  151
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-氯异烟酸 在 乙醇 、 水 、 碘 、 potassium hydrosulfide 、 potassium iodide 作用下， 生成 2,2'-disulfanediyl-di-isonicotinic acid
  参考文献：
  名称：

  Nuclear Substitution Derivatives of Isonicotinic Acid

  摘要：

  DOI：

  10.1021/jo01095a019

文献信息

• Conjugate having cytotoxicity and process for the preparation thereof
  申请人：TEIJIN LIMITED

  公开号：EP0112720A2

  公开（公告）日：1984-07-04

  A conjugate having cytotoxicity prepared by covalently binding a polymer which has cytotoxic substances linked to its side chains and a reactive group at its terminal to an immunoglobulin, or its fragment, which is capable of selectively binding to a particular antigen possessed by cells to be killed.

  一种具有细胞毒性的共轭物，其制备方法是将一种聚合物与免疫球蛋白或其片段共价结合，免疫球蛋白或其片段的侧链上连接有细胞毒性物质，末端连接有活性基团，而免疫球蛋白或其片段能够选择性地与要杀死的细胞所具有的特定抗原结合。
• METHOD OF IMMUNOMODULATION USING THIONE-FORMING DISULFIDES
  申请人：The GRASSETTI Family Trust

  公开号：EP1383499B1

  公开（公告）日：2013-03-06
• Method of immunomodulation using thione-forming disulfides
  申请人：——

  公开号：US20040265327A1

  公开（公告）日：2004-12-30

  The invention provides for the methods of modulating an immune response in an individual by administration of a thione-forming disulfide (TFD). Immunomodulatory responses include, but are not limited to, increased natural killer cell activity, expansion of NK cell population, decreased B cell population, decreased antibody production, and increased mitogenic potential. Methods of modulating such immune responses and the uses of immunomodulation are provided herein.
• Inhibition of IL-1 Induced Inflammation
  申请人：THIOLAB, LLC.

  公开号：US20220193060A1

  公开（公告）日：2022-06-23

  This invention provides methods of treatment for a variety of inflammation pathologies using thione-forming disulfides (TFDs). The treatments are particularly effective in the context of inflammations primarily due to excessive activity of innate immune system components, macrophage activity and inflammation arising from excessive production of IL-1. TFD inhibition of both IL-1 and IL-6 can reduce the detrimental effects of the cytokine storms known to increase morbidity and mortality caused by certain infections, such as COVID-19 viral pneumonia.
• US4152439A
  申请人：——

  公开号：US4152439A

  公开（公告）日：1979-05-01