1-[5-(3-methoxyphenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl]-3-methylurea | 1209487-63-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-[5-(3-methoxyphenyl)-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl]-3-methylurea
• CAS: 1209487-63-7
• 化学式: C₁₅H₁₉N₅O₂
• 分子量: 301.348
• InChiKey: PBVJTHVDTHLEEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• RING-FUSED AZOLE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY
  申请人：Shionogi&Co., Ltd.

  公开号：EP2327704A1

  公开（公告）日：2011-06-01

  It is an object of the present invention to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prophylaxis/therapy of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. The above problem was solved by providing a ring-fused azole compound shown in the present specification, or a pharmaceutically acceptable salt thereof.

  本发明的目的是提供一种化合物或其药学上可接受的盐，它能抑制 PI3K 的活性，从而调节许多生物过程，包括细胞的生长、分化、存活、增殖、迁移、新陈代谢等，因此可用于疾病的预防/治疗，包括炎症性疾病、动脉硬化、血管/循环系统疾病、癌症/肿瘤、免疫系统疾病、细胞增殖性疾病、传染性疾病等。通过提供本说明书所示的环融唑类化合物或其药学上可接受的盐，上述问题得以解决。