(3aS,4S,6R,6aR)-2-methyl-6-(2-pyridyl)-4-m-tolylpyrrolo-octahydropyrrolo[3,4-c]pyrrole-1,3-dione | 1256973-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3aS,4S,6R,6aR)-2-methyl-6-(2-pyridyl)-4-m-tolylpyrrolo-octahydropyrrolo[3,4-c]pyrrole-1,3-dione
• 英文别名: (1S,3R,3aR,6aS)-5-methyl-1-(3-methylphenyl)-3-pyridin-2-yl-2,3,3a,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-4,6-dione
• CAS: 1256973-84-8
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: PSRVEJJZOYPSCA-HZMVEIRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  62.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基马来酰亚胺 、 (E)-N-(3-methylphenyl)methylene-1-(2-pyridyl)methanamine 在 tetrakis(actonitrile)copper(I) hexafluorophosphate 、 三乙胺 、 2,2′-亚甲基双[(4R,5S)-4,5-二苯基-2-噁唑啉] 作用下， 以 二氯甲烷 为溶剂， 以83%的产率得到(3aS,4S,6R,6aR)-2-methyl-6-(2-pyridyl)-4-m-tolylpyrrolo-octahydropyrrolo[3,4-c]pyrrole-1,3-dione
  参考文献：
  名称：

  N-(2-Pyridylmethyl)imines as Azomethine Precursors in Catalytic Asymmetric [3 + 2] Cycloadditions

  摘要：

  An efficient Cu(I)-catalyzed asymmetric [3 + 2] cycloaddition of N-(2-pyridylmethyl) imines has been developed. In the presence of a Cu(CH3CN)(4)PF6/bisoxazoline catalyst system, high levels of enantioselectivity (up to 97% ee) and moderate to high exo selectivity were achieved with a wide variety of substituted dipolarophiles, including maleimides, fumarates, fumarodinitrile, enones, and nitroalkenes. The reaction with unsymmetrically substituted dipolarophiles is completely regioselective.

  DOI：

  10.1021/ol102605q

文献信息

• <i>N</i>-(2-Pyridylmethyl)imines as Azomethine Precursors in Catalytic Asymmetric [3 + 2] Cycloadditions
  作者：Silvia Padilla、Rubén Tejero、Javier Adrio、Juan C. Carretero

  DOI：10.1021/ol102605q

  日期：2010.12.17

  An efficient Cu(I)-catalyzed asymmetric [3 + 2] cycloaddition of N-(2-pyridylmethyl) imines has been developed. In the presence of a Cu(CH3CN)(4)PF6/bisoxazoline catalyst system, high levels of enantioselectivity (up to 97% ee) and moderate to high exo selectivity were achieved with a wide variety of substituted dipolarophiles, including maleimides, fumarates, fumarodinitrile, enones, and nitroalkenes. The reaction with unsymmetrically substituted dipolarophiles is completely regioselective.