naphtho[1,2-b]thiophene S,S-dioxide | 96484-18-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: naphtho[1,2-b]thiophene S,S-dioxide
• 英文别名: naphtho[1,2-b]thiophene-1,1-dioxide；Naphtho[1,2-b]thiophen-1,1-dioxid；Naphtho<1,2-b>thiophen-1,1-dioxid；Naphtho<1.2-b>thiophen-1,1-dioxid；Benzo[g][1]benzothiole 1,1-dioxide；benzo[g][1]benzothiole 1,1-dioxide
• CAS: 96484-18-3
• 化学式: C₁₂H₈O₂S
• 分子量: 216.26
• InChiKey: ZLPDGTCEROFPNH-UHFFFAOYSA-N

物化性质

• 熔点：
  179-180 °C
• 沸点：
  471.7±28.0 °C(Predicted)
• 密度：
  1.418±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  naphtho[1,2-b]thiophene S,S-dioxide 在 邻二氯苯 作用下， 生成 9,9-dioxo-8a,15b-dihydro-9λ6-naphtho[1,2-b]phenanthro[4,3-d]thiophene
  参考文献：
  名称：

  514.噻吩衍生物的聚合。第五部分：4：5-和6：7-苯并硫代环烷1：1-二氧化物的自缩合。合成1-1'和4-2'-萘菲的新途径

  摘要：

  DOI：

  10.1039/jr9560002609
• 作为产物：
  描述：

  2,3-dihydronaphtho<1,2-b>thiophene-S,S-dioxide 在 lithium aluminium tetrahydride 、 乙醚 、 双氧水 、 四氯苯醌 、 溶剂黄146 作用下， 生成 naphtho[1,2-b]thiophene S,S-dioxide
  参考文献：
  名称：

  Banfield et al., Journal of the Chemical Society, 1956, p. 2603,2607

  摘要：

  DOI：

文献信息

• Diels–Alder Reaction of 1,3-Diarylbenzo[<i>c</i>]furans with Thiophene <i>S,S</i>-Dioxide/Indenone Derivatives: A Facile Preparation of Substituted Dibenzothiophene <i>S,S</i>-Dioxides and Fluorenones
  作者：Meganathan Nandakumar、Jayachandran Karunakaran、Arasambattu K. Mohanakrishnan

  DOI：10.1021/ol501175q

  日期：2014.6.6

  One pot syntheses of substituted dibenzothiophene S,S-dioxides and fluorenones were successfully achieved by Diels–Alder reaction of benzo[c]furans with thiophene S,S-dioxides and indenones, respectively. Photophysical properties of representative seven- and nine-membered dibenzothiophene S,S-dioxide acenes were also reported.

  通过苯并[ c ]呋喃的狄尔斯-阿尔德反应分别与噻吩S，S-二氧化物和茚满酮进行Diels-Alder反应，成功地完成了一锅合成取代的二苯并噻吩S，S-二氧化物和芴酮的反应。还报道了代表性的七元和九元二苯并噻吩S，S-二氧化物并苯的光物理性质。
• Sample plate
  申请人：BP OIL INTERNATIONAL LIMITED

  公开号：EP2008716A1

  公开（公告）日：2008-12-31

  A sample plate, and portable apparatus comprising a sample plate and a base portion, which sample plate comprises a sample inlet, a reaction zone, an analysis zone, and at least one separation zone, the sample plate being adapted to allow; (a) a sample fluid to be fed to the sample plate through the inlet to the reaction zone or optionally to a separation zone, which separation zone separates the sample fluid into two or more fractions at least one of which is fed to the reaction zone; (b) a reactant to be fed to the reaction zone; (c) the reaction zone to be maintained under conditions that enable reaction to occur between the reactant and the sample fluid or fraction thereof to produce a product fluid; and (d) transfer of the product fluid to the analysis zone or optionally to a separation zone in which the product fluid is separated into two or more fractions, at least one of which is transferred to the analysis zone.

  一种样品板和便携式仪器，包括一个样品板和一个底座部分，该样品板包括一个样品入口、一个反应区、一个分析区和至少一个分离区，样品板可允许 (a) 样品流体通过进样口进入样品板，然后进入反应区或选择进入分离区，分离区将 样品流体分离成两个或多个馏分，其中至少一个馏分进入反应区； (b) 进入反应区的反应物； (c) 反应区保持在一定条件下，使反应物与样品流体或其馏分发生反应，生成产 品流体；以及 (d) 将产品流体转移到分析区，或选择性地转移到分离区，在分离区内将产品流体分 离成两个或多个馏分，其中至少一个馏分转移到分析区。
• SAMPLE PLATE
  申请人：Drese Klaus-Stefan

  公开号：US20100136699A1

  公开（公告）日：2010-06-03

  A sample plate, portable analysis apparatus and method of analysing sulphur and/or nitrogen compounds in a sample fluid, the method comprising feeding a sample fluid to a sample plate having a sample inlet, a reaction zone, an analysis zone, and at least one separation zone, the sample plate being adapted to allow; (a) a sample fluid to be fed to the sample plate through the inlet to the reaction zone or optionally to a separation zone, which separation zone separates the sample fluid into two or more fractions at least one of which is fed to the reaction zone; (b) a reactant to be fed to the reaction zone; (c) the reaction zone to be maintained under conditions that enable reaction to occur between the reactant and the sample fluid or fraction thereof to produce a product fluid; and (d) transfer of the product fluid to the analysis zone or optionally to a separation zone in which the product fluid is separated into two or more fractions, at least one of which is transferred to the analysis zone.
• PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY AND NOVEL INTERMEDIATES AND METHODS RELATED THERETO
  申请人：VERA THERAPEUTICS, INC.

  公开号：US20210171437A1

  公开（公告）日：2021-06-10

  The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethy-(TCE), 2,2,2-tribromoethyl-(TBE), 2-iodoethyl-groups (2-IE) and 2-bromoethyl-(2-BrE) as the ester group. These particular ester groups can be removed under conditions where both Boc and Fmoc protected amine groups are stable.
• PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY
  申请人：VERA THERAPEUTICS, INC.

  公开号：US20210206809A1

  公开（公告）日：2021-07-08

  This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that permit typical backbone and side chain acid- and base-labile protecting groups to remain substantially intact thereby permitting the high yield of PNA monomer carboxylic acids that are suitable for use in PNA oligomer synthesis. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethyl (TCE), 2,2,2-tribromoethyl (TBE), 2-bromoethyl (2-BE) and 2-iodoethyl groups (2-IE). This invention also pertains to novel methods for the synthesis of Backbone Ester compounds and related Backbone Ester Acid Salts.