5-(3-(2,2-difluorobenzo[1,3]dioxol-5-yl)phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine formate | 1392105-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 5-(3-(2,2-difluorobenzo[1,3]dioxol-5-yl)phenyl)-5-methyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine formate
• 英文别名: 5-[3-(2,2-Difluoro-1,3-benzodioxol-5-yl)phenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine;formic acid
• CAS: 1392105-52-0
• 化学式: CH₂O₂*C₁₈H₁₆F₂N₂O₃
• 分子量: 392.359
• InChiKey: GKQCGKRPBNUOQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.98
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS
  申请人：Andreini Matteo

  公开号：US20120196863A1

  公开（公告）日：2012-08-02

  The present invention provides 1,4 Oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

  本发明提供了具有BACE1和/或BACE2抑制活性的式I的1,4噁嗪，以及它们的制备方法、含有它们的药物组合物以及它们作为治疗活性物质的用途。本发明的活性化合物在治疗和/或预防治疗例如阿尔茨海默病和2型糖尿病等疾病中是有用的。
• US8399459B2
  申请人：——

  公开号：US8399459B2

  公开（公告）日：2013-03-19
• [EN] 1,4 OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS<br/>[FR] 1,4-OXAZINES EN TANT QU'INHIBITEURS DE BACE1 ET/OU BACE2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012104263A2

  公开（公告）日：2012-08-09

  The present invention relates to 1,4 Oxazines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.