2,6-Dichloro-5-fluoropyridine-3-carboxaldehyde | 1260758-33-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-Dichloro-5-fluoropyridine-3-carboxaldehyde
• 英文别名: 2,6-dichloro-5-fluoropyridine-3-carbaldehyde
• CAS: 1260758-33-5
• 化学式: C₆H₂Cl₂FNO
• 分子量: 193.99
• InChiKey: PVYGHERNXKCTOM-UHFFFAOYSA-N

物化性质

• 沸点：
  266.5±35.0 °C(Predicted)
• 密度：
  1.584±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP2022793A1

  公开（公告）日：2009-02-11

  Disclosed is a compound represented by the general formula: [wherein R1 represents an aryl or heterocyclic group which may be substituted or the like; X1 represents a C2-C4 alkylene group or the like; X2, X3 and X5 independently represent NH, a bond or the like; X4 represents a lower alkylene group, a bond or the like; Y1 represents a bivalent alicyclic hydrocarbon residue which may be substituted or a bivalent alicyclic amine residue which may be substituted; and Z1, Z2, Z3, Z4, Z5 and Z6 independently represent a nitrogen atom, a group represented by the formula: CH, or the like, provided that at least one of Z3, Z4, Z5 and Z6 represents a nitrogen atom] or a salt thereof, which is useful as an antibacterial agent.

  本发明公开了一种由通式表示的化合物：[其中 R1 代表可被取代的芳基或杂环基团或类似物；X1 代表 C2-C4 亚烷基或类似物；X2、X3 和 X5 独立地代表 NH、键或类似物；X4 代表低级亚烷基、键或类似物；Y1代表可被取代的二价脂环烃残基或可被取代的二价脂环胺残基；以及 Z1、Z2、Z3、Z4、Z5 和 Z6 独立地代表氮原子、由式：CH，或类似物，条件是 Z3、Z4、Z5 和 Z6 中至少有一个代表氮原子]或其盐，可用作抗菌剂。
• PROCESS FOR THE PREPARATION OF NICOTINIC ACIDS
  申请人：Abbott Laboratories

  公开号：EP0968189A1

  公开（公告）日：2000-01-05
• ANTIMICROBIAL QUINOLONES
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1341781A1

  公开（公告）日：2003-09-10
• [EN] IMPROVED PROCESS FOR THE SYNTHESIS OF 2,6-DICHLORO-5-FLUORONICOTINIC ACID AND 2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE<br/>[FR] PROCEDE DE SYNTHESE AMELIORE D'ACIDE 2,6-DICHLORO-5-FLUORONICOTINIQUE ET DE CHLORURE DE 2,6-DICHLORO-5-FLUORONICOTINOYLE
  申请人：WARNER-LAMBERT COMPANY

  公开号：WO1994004501A1

  公开（公告）日：1994-03-03

  (EN) An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.(FR) Procédé de préparation amélioré de chlorure de 2,6-dichloro-5-fluoronicotinoyle, selon lequel un ester d'acide 2,6-dihydroxy-5-fluoronicotinique est converti en une étape, au moyen d'oxychlorure de phosphore et d'un réactif au lithium, en chlorure de 2,6-dichloro-5-fluoronicotinoyle; l'acide 2,6-dichloro-5-fluoronicotinique est obtenu par une hydrolyse basique ultérieure.
• [EN] PROCESS FOR THE PREPARATION OF NICOTINIC ACIDS<br/>[FR] PROCEDE POUR PREPARER DES ACIDES NICOTINIQUES
  申请人：ABBOTT LABORATORIES

  公开号：WO1998039298A1

  公开（公告）日：1998-09-11

  (EN) The present invention relates to an improved process for the preparation of nicotinic acids represented by structural formula (I) which are prepared by reacting a nicotinic amide compound having formula (a) under acidic conditions with a nitrite salt. In the process of the invention the groups R1, R2, and R3, in the compounds are independently selected from the group consisting of hydrogen and halogen atoms, and R4 is selected from the group consisting of hydrogen, lower alkyl and aryl. The process provides the nicotinic acid compounds in improved yields.(FR) L'invention concerne un procédé amélioré permettant de préparer des acides nicotiniques représentés par la formule structurelle (I), selon lequel on fait réagir un composé d'amide nicotinique de formule (a) avec un nitrite dans des conditions acides. Selon le procédé de l'invention, les groupes R1, R2 et R3 des composés sont choisis indépendamment dans le groupe comprenant l'hydrogène et les atomes d'halogène, et R4 est choisi dans le groupe comprenant hydrogène, alkyle inférieur et aryle. Le procédé permet de produire des acides nicotiniques avec un meilleur rendement.