Icapamespib I-124 | 1450804-65-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: Icapamespib I-124
• 英文别名: 9-[2-(2,2-dimethylpropylamino)ethyl]-8-[(6-(124I)iodanyl-1,3-benzodioxol-5-yl)sulfanyl]purin-6-amine
• CAS: 1450804-65-5
• 化学式: C₁₉H₂₃IN₆O₂S
• 分子量: 523.497
• InChiKey: UYODNJZBUUEXPC-ZEMUAQPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  tert-butyl N-[2-[6-amino-8-[(6-(124I)iodanyl-1,3-benzodioxol-5-yl)sulfanyl]purin-9-yl]ethyl]-N-(2,2-dimethylpropyl)carbamate 在 三氟乙酸 作用下， 反应 1.0h， 生成 Icapamespib I-124
  参考文献：
  名称：

  USES OF LABELED HSP90 INHIBITORS

  摘要：

  公开号：

  EP3208615B1

文献信息

• HSP90-TARGETED CARDIAC IMAGING AND THERAPY
  申请人：MEMORIAL SLOAN-KETTERING CANCER CENTER

  公开号：US20160015837A1

  公开（公告）日：2016-01-21

  The present invention provides new methods for cardiac imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of cardiovascular diseases, conditions, or disorders. In some embodiments, the present invention provides a method for the treatment or prevention of cardiovascular diseases, conditions, or disorders. In some embodiments, the present invention provides methods for monitoring the effect of cancer treatment on the heart, and/or methods for monitoring a cancer treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for a test or treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug. In some embodiments, the present invention provides methods for determining the risk of a cardiovascular disease, for assessing risk of a cardiovascular disease, and/or for determining the risk of heart attack.

  本发明提供了心脏成像的新方法及相关的医疗应用。在某些实施例中，本发明提供了一种用于诊断心血管疾病、症状或障碍的方法。在某些实施例中，本发明提供了一种用于治疗或预防心血管疾病、症状或障碍的方法。在某些实施例中，本发明提供了用于监测癌症治疗对心脏的影响的方法，和/或用于监测癌症治疗方案的方法。在某些实施例中，本发明提供了一种用于选择测试对象或治疗的方法。在某些实施例中，本发明提供了一种确定药物剂量的方法。在某些实施例中，本发明提供了用于确定心血管疾病风险、评估心血管疾病风险和/或确定心脏病发风险的方法。
• HSP90-TARGETED INFLAMMATION AND INFECTION IMAGING AND THERAPY
  申请人：Memorial Sloan Kettering Cancer Center

  公开号：US20170304470A1

  公开（公告）日：2017-10-26

  The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
• US9555137B2
  申请人：——

  公开号：US9555137B2

  公开（公告）日：2017-01-31