3-hydroxy-1-phenyl-2-hexanone | 106942-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-hydroxy-1-phenyl-2-hexanone
• 英文别名: 3-Hydroxy-1-phenylhexan-2-one
• CAS: 106942-16-9
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: PPAGIGKEADZPGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-Bromo-1-phenylhexan-2-one 在 水 作用下， 以75%的产率得到3-hydroxy-1-phenyl-2-hexanone
  参考文献：
  名称：

  微波辅助从α-卤代和α，α'-二溴代酮合成α-羟基酮，α-二酮和吡嗪衍生物

  摘要：

  微波辐射下α-卤代酮（α-溴代和α-氯代酮）的新型反应可得到相应的α-羟基酮和吡嗪衍生物，收率很高。在α，α′-二溴酮的情况下，获得了α-二酮。该反应为α-羟基酮，α-二酮，α-氯酮和吡嗪衍生物的合成提供了一种新的，清洁且方便的方法。

  DOI：

  10.1016/j.tetlet.2006.10.087

文献信息

• Addition of organomagnesium reagents to cyanohydrin--silyl ethers: An efficient and flexible synthesis of unsymmetrically substituted acyloins
  作者：Melvyn Gill、Milton J Kiefel、Deborah A Lally

  DOI：10.1016/s0040-4039(00)84415-9

  日期：1986.1

  Acyloins are prepared in high yields reaction between Grignard reagents and -trimethylsilyl ethers of aldehyde cyanohydrins: the method is particularly useful for the preparation of discrete acyloins in which the substituents are unsymmetrically disposed about the α-hydroxyketone moiety.

  醛缩蛋白是通过格氏试剂与醛氰醇的-三甲基甲硅烷基醚之间的高收率反应制备的：该方法特别适用于制备其中取代基在α-羟基酮部分周围不对称分布的离散酰基缩醛。
• Synthesis of 2‑Boryl Allylboronates by a Bimetallic Platinum/Zinc-Promoted Diborylation of Propargylic Amines
  作者：Chun-Xiang Zhuo、Xiao-Nan Shi、Jia-Le Wang、Jiang-Bin Wu

  DOI：10.1055/a-2030-6797

  日期：——

  2‑Boryl allylboronates, which contain both a C(sp2)–B bond and a C(sp3)–B bond, are attractive synthetic intermediates due to their diverse reactivity profiles toward a wide range of organic transformations. We report a facile approach to (Z)-2‑boryl allylboronates through a Pt/Zn-promoted diborylation reaction of readily available propargylic amines. An array of valuable (Z)-2‑boryl allylboronates were

  含有 C(sp2)–B 键和 C(sp3)–B 键的 2‑Boryl allylboronates 是有吸引力的合成中间体，因为它们对广泛的有机转化具有不同的反应特性。我们报告了一种通过 Pt/Zn 促进的现成炔丙胺的二硼化反应生成 (Z)-2-硼烷基烯丙基硼酸酯的简便方法。在 2.5 mol% 的 Pt(PPh3)4 和 50 mol% 的 ZnBr2 存在下，以高达 73% 的收率获得了一系列有价值的 (Z)-2-boryl allylboronates。
• Asymmetric acyloin condensation catalysed by phenylpyruvate decarboxylase. Part 2: Substrate specificity and purification of the enzyme
  作者：Zhiwei Guo、Animesh Goswami、Venkata B Nanduri、Ramesh N Patel

  DOI：10.1016/s0957-4166(01)00095-7

  日期：2001.3

  Phenylpyruvate decarboxylase from Achromobacter eurydice was used to catalyse the asymmetric acyloin condensation of phenylpyruvate 1 with Various aldehydes 2 to produce optically active acyloins PhCH2COCH(OH)R 3. The specific activity of the phenylpyruvate decarboxylase enzyme was increased by a factor of 332 after its purification. The molecular weight of the purified enzyme was shown to be 150 kDa by gel filtration chromatography, while SDS gel electrophoresis showed two sub-units with molecular weights of 90 and 40 kDa. The acyloin condensation yield decreased with increasing chain length for straight chain aliphatic aldehydes from 76% for acetaldehyde to 24% for valeraldehyde. The e.e.s of the acyloin products were 87-98%. Low yields of acyloin products were obtained with chloroacetaldehyde (13%) and glycoaldehyde (16%). Indole-3-pyruvate was a substrate of the enzyme and provided acyloin condensation product 3-hydroxy-1-(3-indolyl)-2-butanone 5 with acetaldehyde in 19% yield, while benzoylformate was not a substrate for the enzyme. (C) 2001 Elsevier Science Ltd. All rights reserved.
• GILL, M.;KIEFEL, M. J.;LALLY, D. A., TETRAHEDRON LETT., 1986, 27, N 17, 1933-1934
  作者：GILL, M.、KIEFEL, M. J.、LALLY, D. A.

  DOI：——

  日期：——
• [EN] METHODS AND COMPOSITIONS FOR GROWTH OF YEAST ON ALGINATE<br/>[FR] PROCÉDÉS ET COMPOSITIONS DE CROISSANCE DE LEVURE SUR UN ALGINATE
  申请人：BIO ARCHITECTURE LAB INC

  公开号：WO2013115959A1

  公开（公告）日：2013-08-08

  The present disclosure relates to the degradation of alginate by yeast. In particular, the present disclosure relates to methods of growing yeast on oligoalginate and recombinant yeast cells capable of growing on oligoalginate by expressing one or more proteins in an alginate metabolic pathway.