N'-((6aR,10aR)-1-hydroxy-6,6-dimethyl-3-pentyl-6,6a,7,8,10,10a-hexahydro-9H-benzo[c]chromen-9-ylidene)-2,4,6-triisopropylbenzenesulfonohydrazide | 949595-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: N'-((6aR,10aR)-1-hydroxy-6,6-dimethyl-3-pentyl-6,6a,7,8,10,10a-hexahydro-9H-benzo[c]chromen-9-ylidene)-2,4,6-triisopropylbenzenesulfonohydrazide
• CAS: 949595-94-2
• 化学式: C₃₅H₅₂N₂O₄S
• 分子量: 596.875
• InChiKey: VWQWOPGQXXAYMN-LOYHVIPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.88
• 重原子数：
  42.0
• 可旋转键数：
  10.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  87.99
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  二氧化碳 、 N'-((6aR,10aR)-1-hydroxy-6,6-dimethyl-3-pentyl-6,6a,7,8,10,10a-hexahydro-9H-benzo[c]chromen-9-ylidene)-2,4,6-triisopropylbenzenesulfonohydrazide 在 正丁基锂 、 四甲基乙二胺 作用下， 以 正己烷 为溶剂， 以54%的产率得到(-)-11-n-9-羧基-δ9-THC
  参考文献：
  名称：

  Preparation of Racemic, (−)- and (+)-11-Nor-Δ⁹-Tetrahydrocannabinol- 9-carboxylic Acid

  摘要：

  DOI：

  10.1021/jo970969e
• 作为产物：
  描述：

  dl-6aα,7,10,10aα-Tetrahydro-1-hydroxy-6,6-dimethyl-3-pentyl-6H-dibenzo[b,d]pyran-9(8H)-on 在 高氯酸 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 乙醇 、 甲苯 为溶剂， 反应 28.48h， 生成 N'-((6aR,10aR)-1-hydroxy-6,6-dimethyl-3-pentyl-6,6a,7,8,10,10a-hexahydro-9H-benzo[c]chromen-9-ylidene)-2,4,6-triisopropylbenzenesulfonohydrazide
  参考文献：
  名称：

  Preparation of Racemic, (−)- and (+)-11-Nor-Δ⁹-Tetrahydrocannabinol- 9-carboxylic Acid

  摘要：

  DOI：

  10.1021/jo970969e

文献信息

• A concise methodology for the synthesis of (−)-Δ9-tetrahydrocannabinol and (−)-Δ9-tetrahydrocannabivarin metabolites and their regiospecifically deuterated analogs
  作者：Spyros P. Nikas、Ganesh A. Thakur、Damon Parrish、Shakiru O. Alapafuja、Marilyn A. Huestis、Alexandros Makriyannis

  DOI：10.1016/j.tet.2007.06.006

  日期：2007.8

  The availability of tetrahydrocannabinols (Delta(9)-THC), tetrahydrocannabivarins (Delta(9)-THCV), and their metabolites in both their undeuterated and deuterated forms is critical for the analysis of biological and toxicological samples. We report here a concise methodology for the syntheses of (-)-Delta(9)-THC and (-)-Delta(9)-THCV metabolites in significantly improved overall yields using commercially available starting materials. Our approach allowed us to obtain the key intermediates (6aR,10aR)-9-nor-9-oxo-hexahydrocannabinols in four steps from (+)-(1R)-nopinone. This was followed by an optimized Shapiro reaction to give the (-)-11-nor-9-carboxy-metabolites, which were converted to their respective (-)-11-hydroxy analogs. The synthetic sequence involves a minimum number of steps, avoids undesirable oxidative conditions, and incorporates the costly deuterated resorcinols near the end of the synthetic sequence. This methodology enabled us to synthesize eight regiospecifically deuterated (-)-Delta(9)-THC and (-)-Delta(9)-THCV metabolites in a preparative scale and high optical purity without deuterium scrambling or loss. (c) 2007 Published by Elsevier Ltd.