(4R,5S)-4-methyl-3-((R)-4-methyl-hexanoyl)-5-phenyl-oxazolidin-2-one | 313653-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4R,5S)-4-methyl-3-((R)-4-methyl-hexanoyl)-5-phenyl-oxazolidin-2-one
• 英文别名: (4R,5S)-4-methyl-3-[(4R)-4-methylhexanoyl]-5-phenyl-1,3-oxazolidin-2-one
• CAS: 313653-17-7
• 化学式: C₁₇H₂₃NO₃
• 分子量: 289.375
• InChiKey: GJOBEUUSTJWCJF-XJKCOSOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Combinations
  申请人：Field John Mark

  公开号：US20050065176A1

  公开（公告）日：2005-03-24

  The instant invention relates to a combination of an alpha-2-delta ligand and an AChE inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred ACHE inhibitors are donepezil (Aricept®), tacrine (cognex®), rivastigmine (Exelon®), physostgmine (Synapton®), galantamine (Reminyl), metrifonate (Promem), neostigmine (Prostigmin) and icopezil.

  该瞬时发明涉及一种α-2-δ配体和AChE抑制剂的组合，用于治疗，特别是用于治疗疼痛，特别是神经病性疼痛的治疗。特别偏爱的α-2-δ配体是加巴喷丁和普雷加巴林。特别偏爱的ACHE抑制剂包括多奈哌齐（阿力普特®）、他克林（可格林®）、利伐司特（埃克洛尔®）、生理毒素（斯纳普通®）、加兰他明（瑞莫灵）、美曲磷（普罗美）、新斯的明（普罗斯的明）和伊科唑。
• Combinations comprising alpha-2-delta ligands
  申请人：Dooley James David

  公开号：US20050059715A1

  公开（公告）日：2005-03-17

  The instant invention relates to a combination, particularly a synergistic combination, of an alpha-2-delta ligand and a dual serotonin-noradrenaline re-uptake inhibitor (DSNRI) or one or both of a selective serotonin re-uptake inhibitor (SSRI) and a selective noradrenaline re-uptake inhibitor (SNRI), and pharmaceutically acceptable salths thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain.

  该发明涉及一种组合，特别是α-2-δ配体和双重5-羟色胺-去甲肾上腺素再摄取抑制剂（DSNRI）或选择性5-羟色胺再摄取抑制剂（SSRI）和/或选择性去甲肾上腺素再摄取抑制剂（SNRI）的协同组合，以及其药学上可接受的盐，药物组合物及其在特别是神经痛治疗中的用途。
• Synergistic combinations
  申请人：——

  公开号：US20040157847A1

  公开（公告）日：2004-08-12

  The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the curative, prophylactic or palliative treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. Particularly preferred PDEV inhibitors are sildenafil, vardenafil and tadalafil.

  这项瞬时发明涉及α-2-δ配体和PDEV抑制剂的组合，用于治疗，特别是在疼痛的治疗、预防或缓解中，特别是神经病性疼痛。特别偏好的α-2-δ配体是加巴喷丁和普雷加巴林。特别偏好的PDEV抑制剂是西地那非、伐地那非和他达拉非。
• Amino acids with affinity for the alpha-2-delta-protein
  申请人：——

  公开号：US20030195251A1

  公开（公告）日：2003-10-16

  This invention relates to certain &bgr;-amino acids that bind to the alpha-2-delta (&agr;2&dgr;) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

  这项发明涉及与钙通道的α-2-δ（α2δ）亚基结合的某些β-氨基酸。这些化合物及其药用盐在治疗各种精神疾病、疼痛和其他疾病方面具有用处。
• Method of treating tinnitus
  申请人：Dooley James David

  公开号：US20060100281A1

  公开（公告）日：2006-05-11

  The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

  本发明涉及一种通过给予α2δ配体治疗耳鸣的方法，例如，给予公式中的化合物及其药学上可接受的盐，其中R1为氢或直链或支链低碳基，n为4到6的整数。