(3S,4R)-N-Cbz-3-(4-Phenoxybenzenesulfonamido)-4-mercaptopyrrolidine | 1214272-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,4R)-N-Cbz-3-(4-Phenoxybenzenesulfonamido)-4-mercaptopyrrolidine
• 英文别名: benzyl (3S,4R)-3-[(4-phenoxyphenyl)sulfonylamino]-4-sulfanylpyrrolidine-1-carboxylate
• CAS: 1214272-31-7
• 化学式: C₂₄H₂₄N₂O₅S₂
• 分子量: 484.597
• InChiKey: FOQIDDVNVMCVNJ-XZOQPEGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  94.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Substituted Heterocyclic Mercaptosulfonamide Metalloprotease Inhibitors
  申请人：Schwartz Martin A.

  公开号：US20110144179A1

  公开（公告）日：2011-06-16

  The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These compounds are designed to be potent selective inhibitors of matrix metalloproteinases (MMPs), including, for example, gelatinases, collagenases, matrilysins, metalloelastase, stromelysin, and membrane-type 1 matrix metalloproteinase. These inhibitors may be used for the control of physiological and pathological processes and disease conditions in which MMPs are believed to play significant functions.

  本发明一般涉及取代的杂环巯基磺酰胺化合物、前体及其衍生物，以及制备这些化合物的方法和包含这些化合物的药物组合物。这些化合物被设计为强效的选择性基质金属蛋白酶（MMPs）抑制剂，包括例如明胶酶、胶原酶、基质溶素、金属弹性蛋白酶、基质溶素和膜型1基质金属蛋白酶。这些抑制剂可用于控制生理和病理过程以及疾病状况，在这些过程中，MMPs被认为发挥着重要作用。
• US8404866B2
  申请人：——

  公开号：US8404866B2

  公开（公告）日：2013-03-26
• [EN] SUBSTITUTED HETEROCYCLIC MERCAPTOSULFONAMIDE METALLOPROTEASE INHIBITORS<br/>[FR] INHIBITEURS MERCAPTOSULFONAMIDES HÉTÉROCYCLIQUES SUBSTITUÉS DE MÉTALLOPROTÉINASE
  申请人：UNIV FLORIDA STATE RES FOUND

  公开号：WO2010028051A2

  公开（公告）日：2010-03-11

  The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These compounds are designed to be potent selective inhibitors of matrix metalloproteinases (MMPs), including, for example, gelatinases, collagenases, matrilysins, metalloelastase, stromelysin, and membrane-type 1 matrix metalloproteinase. These inhibitors may be used for the control of physiological and pathological processes and disease conditions in which MMPs are believed to play significant functions.