Atuliflapon | 2041075-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Atuliflapon
• 英文别名: (1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4-oxo-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide
• CAS: 2041075-86-7
• 化学式: C₂₄H₂₆N₆O₃
• 分子量: 446.5
• InChiKey: ROTWSDMXHVGAHZ-QZTJIDSGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLE UTILES EN TANT QU'INHIBITEURS (FLAP) DE PROTÉINE ACTIVANT LA 5-LIPOXYGÉNASE
  申请人：ASTRAZENECA AB

  公开号：WO2016177703A1

  公开（公告）日：2016-11-10

  The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

  本申请涉及到式(I)的新化合物，以及它们在治疗和/或预防心血管疾病（CVD）等临床疾病方面的用途，以及它们的治疗用途方法，含有它们的药物组合物以及制备这些化合物的过程。
• [EN] CRYSTALLINE FORM OF (1R,2R)-2-[4-(3-METHY1-1H-PYRAZOL-5-YL)BENZOYL]-N-(4-OXO-4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZIN-3-YL)CYCLOHEXANECARBOXAMIDE<br/>[FR] FORME CRISTALLINE DE (1R,2R)-2-[4- (3-MÉTHYL-1H-PYRAZOL-5-YL)BENZOYL]-N-(4-OXO -4,5,6,7-TÉTRAHYDROPYRAZOLO[1,5-A]PYRAZIN-3-YL)CYCLOHEXANECARBOXAMIDE
  申请人：ASTRAZENECA AB

  公开号：WO2018078097A1

  公开（公告）日：2018-05-03

  A crystalline form of (1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-α]pyrazin-3-yl)cyclohexanecarboxamide, pharmaceutical compositions containing it and its use in therapy.

  (1R,2R)-2-[4-(3-甲基-1H-吡唑-5-基)苯甲酰基]-N-(4-氧代-4,5,6,7-四氢吡唑并[1,5-α]吡嗪-3-基)环己基甲酰胺的结晶形式，含有它的药物组合物以及其在治疗中的用途。
• Pyrazole derivatives useful as 5-lipoxygenase activating protein (FLAP) inhibitors
  申请人：ASTRAZENECA AB

  公开号：US10183947B2

  公开（公告）日：2019-01-22

  The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

  本申请涉及式 (I) 的新型化合物 在治疗和/或预防包括心血管疾病 (CVD) 在内的临床病症方面的用途、治疗方法、含有这些化合物的药物组合物以及制备这些化合物的工艺。
• Crystalline form of (1R,2R)-2-[4-(3-methyl-1H-pyrazol-5-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-A]pyrazin-3-yl)cyclohexanecarboxamide
  申请人：AstraZeneca AB

  公开号：US10689387B2

  公开（公告）日：2020-06-23

  A crystalline form of (1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5-yl)benzoyl]-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexanecarboxamide, pharmaceutical compositions containing it and its use in the prevention or treatment of cardiovascular diseases.

  (1R,2R)-2-[4-(3-甲基-1H-吡唑-5-基)苯甲酰基]-N-(4-氧代-4,5,6,7-四氢吡唑并[1,5-a]吡嗪-3-基)环己甲酰胺的结晶形式、含有该物质的药物组合物及其在预防或治疗心血管疾病中的用途。
• PYRAZOLE DERIVATIVES USEFUL AS 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITORS
  申请人：AstraZeneca AB

  公开号：EP3292105B1

  公开（公告）日：2019-10-02