3-{(Z)-1-[5-(tert-butyl)-1H-4-oxazolyl]methylidene}-6-[(Z)-1-(9-anthryl)methylidene]-2,5-piperazinedione | 930591-36-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 3-{(Z)-1-[5-(tert-butyl)-1H-4-oxazolyl]methylidene}-6-[(Z)-1-(9-anthryl)methylidene]-2,5-piperazinedione
• 英文别名: (3Z,6Z)-3-(anthracen-9-ylmethylidene)-6-[(5-tert-butyl-1,3-oxazol-4-yl)methylidene]piperazine-2,5-dione
• CAS: 930591-36-9
• 化学式: C₂₇H₂₃N₃O₃
• 分子量: 437.498
• InChiKey: BINFJFZWJIHSPO-SJZPPUTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THEAPEUTIC USE
  申请人：Palladino Michael A.

  公开号：US20080221122A1

  公开（公告）日：2008-09-11

  Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

  由以下结构（II）表示的化合物已被披露：制备这种化合物的方法也已被披露。还披露了用于治疗各种疾病条件的组合物和方法，包括与血管增殖相关的癌症和非癌症疾病。
• Analogs of dehydrophenylahistins and their therapeutic use
  申请人：Palladino Michael

  公开号：US20070078138A1

  公开（公告）日：2007-04-05

  Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

  本文揭示了由以下结构（II）所代表的化合物，以及制造这种化合物的方法。此外，还揭示了用于治疗各种疾病状况的组合物和方法，包括与血管增殖有关的癌症和非癌症疾病。
• ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THERAPEUTIC USE
  申请人：Palladino Michael

  公开号：US20120277251A1

  公开（公告）日：2012-11-01

  Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

  本文披露了以下结构（II）所代表的化合物，以及制备这些化合物的方法。此外，还披露了用于治疗各种疾病状况的组合物和方法，包括与血管增生相关的癌症和非癌性疾病。
• TUBULIN BINDING COMPOUNDS AND THERAPEUTIC USE THEREOF
  申请人：BeyondSpring Pharmaceuticals, Inc.

  公开号：US20200237754A1

  公开（公告）日：2020-07-30

  Disclosed herein are compounds that can bind to tubulin and activate GEF-H1. Methods of using these compounds for treating cancer are also disclosed.
• US7919497B2
  申请人：——

  公开号：US7919497B2

  公开（公告）日：2011-04-05