| 299434-10-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• CAS: 299434-10-9
• 化学式: C₃₄H₄₆O₈
• 分子量: 582.734
• InChiKey: KLAZFEWXLKYCJG-YIRVTRDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.86
• 重原子数：
  42.0
• 可旋转键数：
  17.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  73.84
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthesis of New Diols Derived from Dianhydrohexitols Ethers under Microwave-Assisted Phase Transfer Catalysis

  摘要：

  Alkylation of mono-benzylated isosorbide and isomannide was performed under microwave assisted phase transfer catalysis (PTC). A small amount of solvent was necessary to provide good yields (90-96%) within 15 min. In order to minimize the competitive elimination, halide leaving group was changed to tosylate as competitive S(N)2-E2 processes were involved. After removal of benzyl moiety by hydrogenation, a series of new diols fi om dianhydrohexitols were thus prepared. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00539-1
• 作为产物：
  描述：

  1,8-bis(p-toluenesulfonyloxy)octane 、 (3R,3aR,6R,6aR)-6-benzyloxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol 在 氢氧化钾 、 四丁基溴化铵 作用下， 以 甲苯 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  Synthesis of New Diols Derived from Dianhydrohexitols Ethers under Microwave-Assisted Phase Transfer Catalysis

  摘要：

  Alkylation of mono-benzylated isosorbide and isomannide was performed under microwave assisted phase transfer catalysis (PTC). A small amount of solvent was necessary to provide good yields (90-96%) within 15 min. In order to minimize the competitive elimination, halide leaving group was changed to tosylate as competitive S(N)2-E2 processes were involved. After removal of benzyl moiety by hydrogenation, a series of new diols fi om dianhydrohexitols were thus prepared. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00539-1