(2S,3R,4S)-3,5-dimethyl-2-phenyl-3,4-dihydro-2H-pyran-4-ol | 138512-12-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,3R,4S)-3,5-dimethyl-2-phenyl-3,4-dihydro-2H-pyran-4-ol
• CAS: 138512-12-6
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: ZCZKWXJIPYYHIU-RTXFEEFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  15.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (2S,3R,4S)-3,5-dimethyl-2-phenyl-3,4-dihydro-2H-pyran-4-ol 生成 (2R,3S,4R)-3,5-dimethyl-4-hydroxy-2-phenyl-2,3-dihydro-4H-pyran
  参考文献：
  名称：

  Berkowitz, David B.; Danishefsky, Samuel J.; Schulte, Gayle K., Journal of the American Chemical Society, 1992, vol. 114, # 12, p. 4518 - 4529

  摘要：

  DOI：

文献信息

• Enzymatic resolution of racemic glycals: an application of the wong acylation method
  作者：David B. Berkowitz、Samuel J. Danishefsky

  DOI：10.1016/0040-4039(91)80067-g

  日期：1991.9

  Kinetic resolution of racemic, fully synthetic, artificial glycals bearing a free hydroxyl group at C3 was accomplished through the more rapid acylation of the ''D''-antipode with vinyl acetate as acyl donor and Lipase PS-30 from Pseudomonas cepacia as catalyst.
• A concise and stereoselective route to the predominant stereochemical pattern of the tetrahydropyranoid antibiotics: an application to indanomycin
  作者：Samuel J. Danishefsky、Shari DeNinno、Paul Lartey

  DOI：10.1021/ja00241a028

  日期：1987.4