2-benzo[1,3]dioxol-5-yl-3-methylimidazo[1,2-a]pyridine | 1426080-00-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-benzo[1,3]dioxol-5-yl-3-methylimidazo[1,2-a]pyridine
• CAS: 1426080-00-3
• 化学式: C₁₅H₁₂N₂O₂
• 分子量: 252.272
• InChiKey: SXFIJUZDEXOWGN-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 5-((E)-3-Nitro-but-2-enyl)-benzo[1,3]dioxole 在 iron(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以61%的产率得到2-benzo[1,3]dioxol-5-yl-3-methylimidazo[1,2-a]pyridine
  参考文献：
  名称：

  Iron(II)-Catalyzed Denitration Reaction: Synthesis of 3-Methyl-2-arylimidazo[1,2-a]pyridine Derivatives from Aminopyridines and 2-Methylnitroolefins

  摘要：

  A variety of ways to synthesize imidazo[1,2-a]pyridines have been reported and many approaches are devoted to the functionalization of imidazo[1,2-a]pyridines. However, the use of a denitration reaction in the synthesis of imidazo[1,2-a]pyridines has not been reported. We report here the iron-catalyzed synthesis of 3-methyl-2-arylimidazo [1,2-a] pyridine derivatives from aminopyridines and 2-methyl-nitroolefins. The procedure, using FeCl2 as catalyst, is simple and inexpensive. Various functional groups are tolerated and provide the products in good yields.

  DOI：

  10.1055/s-0032-1317685