Hydrazinecarbothioamide, 2-(2-pyridinyl)- | 77133-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Hydrazinecarbothioamide, 2-(2-pyridinyl)-
• 英文别名: (pyridin-2-ylamino)thiourea
• CAS: 77133-64-3
• 化学式: C₆H₈N₄S
• 分子量: 168.22
• InChiKey: GWXJJPUVJRAAPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] HETEROCYCLIC THIOSEMICARBAZONE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS<br/>[FR] DÉRIVÉS DE THIOSEMICARBAZONE HÉTÉROCYCLIQUES ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：NANT HOLDINGS IP LLC

  公开号：WO2017024315A1

  公开（公告）日：2017-02-09

  Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated compounds will be suitable to inhibit or reduce cellular growth or proliferation and are thus beneficial in the manufacture of drugs to treat neoplastic diseases.

  本文介绍了制备各种杂环硫脲类衍生物的药物化合物、组合物和方法。考虑到这些化合物适用于抑制或减少细胞生长或增殖，因此在制造用于治疗肿瘤性疾病的药物方面具有益处。
• Heterocyclic thiosemicarbazone derivatives and their therapeutical applications
  申请人：NANTBIO, INC.

  公开号：US10392397B2

  公开（公告）日：2019-08-27

  Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated compounds will be suitable to inhibit or reduce cellular growth or proliferation and are thus beneficial in the manufacture of drugs to treat neoplastic diseases.

  本发明提出了制备各种杂环硫代氨基羰基衍生物的药物化合物、组合物和方法。 设想的化合物将适用于抑制或减少细胞生长或增殖，因此有利于制造治疗肿瘤性疾病的药物。
• [EN] A BIOCIDAL, PARTICULARLY FUNGICIDAL AND/OR BACTERICIDAL, COMPOSITION
  申请人：A/S CHEMINOVA

  公开号：WO1985004333A1

  公开（公告）日：1985-10-10

  (EN) A biocidal composition, particularly a fungicidal and/or bactericidal composition, comprising a thiosemicarbazide, a thionocarbazate or a dithiocarbazate which, when using the composition, exhibits hitherto unknown biocidal properties. The thiosemicarbazide, thionocarbazate or dithiocarbazate contained in the composition belongs to the group of compounds having the general formula (I), and their complexes formed by reaction with compounds of the metals, Cu, Zn, Mn, Fe, Ca, Mg, Al, Sn and Ti having inorganic and/or organic ligands, and salts of said compounds. The compounds of the invention and particularly their metal complexes exhibit surprising fungicidal and bactericidal activities. They may particularly be used for combating or preventing attacks by fungi or bacteria or plants on plant material, including seed material.(FR) Une composition biocide, plus particulièrement une composition fongicide et/ou bactéricide, comprenant un thiosemicarbazide, un thionocarbazate ou un dithiocarbazate présente des propriétés biocides inconnues jusqu'ici. Le thiosemicarbazide, le thionocarbazate ou le dithiocarbazate contenu dans la composition appartient au groupe des composés ayant la formule générale (I) et leurs complexes formés par la réaction avec des composés des métaux Cu, Zn, Mn, Fe, Ca, Mg, Al, Sn et Ti ayant des liants inorganiques et/ou organiques et les sels de ces composés. Les composés de l'invention et particulièrement leurs complexes métalliques présentent des activités fongicides et bactéricides surprenantes. Ils peuvent être utilisés en particulier pour la lutte ou la prévention d'attaques par des champignons ou des bactéries sur des plantes ou des matériaux végétaux, y compris les graines.

  一种生物杀虫剂，特别是具有杀菌作用的真菌和/or 细菌成分，包含 thiosemicarbazide、thionocarbazate 或 dithiocarbazate，当使用该成分时，具有前所未知的杀菌活性。该成分中的 thiosemicarbazide、thionocarbazate 或 dithiocarbazate 属于具有通用公式的（I）类化合物，与铜、锌、锰、铁、钙、镁、铝、стmium 和钛的金属化合物反应生成其无机和/or 有机配位剂的化合物及其盐。根据本发明的各种化合物及其金属配合物显示出令人惊讶的真菌和细菌杀菌活性。它们尤其可以用来对抗或防止真菌、细菌或植物对植物材料，包括籽粒材料的攻击。
• A BIOCIDAL, PARTICULARLY FUNGICIDAL AND/OR BACTERICIDAL, COMPOSITION
  申请人：A/S CHEMINOVA

  公开号：EP0175725A1

  公开（公告）日：1986-04-02
• HETEROCYCLIC THIOSEMICARBAZONE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
  申请人：NANTBIO, INC.

  公开号：US20180208603A1

  公开（公告）日：2018-07-26

  Pharmaceutical compounds, compositions, and methods are presented in which various heterocyclic thiosemicarbazone derivatives are prepared. Contemplated compounds will be suitable to inhibit or reduce cellular growth or proliferation and are thus beneficial in the manufacture of drugs to treat neoplastic diseases.