2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide | 885055-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-{(4S)-4-[4-(difluoromethoxy)-3-isopropoxyphenyl]-2-oxopyrrolidin-1-yl}-N-(3-fluorophenyl)-N-methylacetamide
• 英文别名: 2-[(4S)-4-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-2-oxopyrrolidin-1-yl]-N-(3-fluorophenyl)-N-methylacetamide
• CAS: 885055-35-6
• 化学式: C₂₃H₂₅F₃N₂O₄
• 分子量: 450.458
• InChiKey: WIYFPHGRVVNVGK-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Phosphodiesterase 4 inhibitors
  申请人：Hopper Allen

  公开号：US20060135535A1

  公开（公告）日：2006-06-22

  Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R 1 , R 2 , and R 3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

  选择性PDE4抑制是通过新型化合物实现的，例如4-(取代苯基)-2-吡咯烷酮化合物。本发明的化合物的公式为I：其中R1，R2和R3如本文所定义。本公开还涉及制备这种化合物的方法，含有这种化合物的组合物以及使用这种化合物的方法。
• PHOSPHODIESTERASE 4 INHIBITORS
  申请人：HOPPER Allen

  公开号：US20090306156A1

  公开（公告）日：2009-12-10

  Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R 1 , R 2 , and R 3 are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

  选择性PDE4抑制是通过新型化合物实现的，例如4-（取代苯基）-2-吡咯烷酮化合物。本发明的化合物具有以下结构式I：其中R1、R2和R3如本文所定义。本公开还涉及制备这种化合物的方法，含有这种化合物的组合物以及使用这种化合物的方法。
• US7585882B2
  申请人：——

  公开号：US7585882B2

  公开（公告）日：2009-09-08
• [EN] PHOSPHODIESTERASE 4 INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHODIÉSTÉRASE 4
  申请人：MEMORY PHARM CORP

  公开号：WO2006044955A1

  公开（公告）日：2006-04-27

  [EN] Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula (I) wherein R[FR] L'inhibition sélective de la PDE4 peut être obtenue à l'aide de nouveaux composés, par exemple les dérivés de 2-pyrrolidinone portant en position 4 un groupement phényle substitué. Les composés décrits dans la présente invention répondent à la formule (I) où R
• [EN] COMBINATIONS OF PDE4 INHIBITORS AND ANTIPSYCHOTICS FOR THE TREATMENT OF PSYCHOTIC DISORDERS<br/>[FR] COMBINAISONS D'INHIBITEURS DE PDE4 ET D'ANTIPSYCHOTIQUES POUR LE TRAITEMENT DE TROUBLES PSYCHOTIQUES
  申请人：MEMORY PHARM CORP

  公开号：WO2009067607A2

  公开（公告）日：2009-05-28

  The invention relates to methods and compositions for treating a psychotic disorder or condition, associated with cognitive impairment. The pharmaceutical composition comprises: (a) an amount of an antipsychotic agent and (b) an amount of a PDE4 inhibitor compound, wherein the amounts of (a) and (b) are together effective in treating the cognitive impairment or psychotic disorder such as schizophrenia. The method of treatment comprises administering to a patient (a) an amount of a antipsychotic agent and (b) an amount of a PDE4 inhibitor compound, wherein the amounts of (a) and (b) are together effective in treating the psychotic disorder such as schizophrenia.