o-(n-butyl)benzhydrazide | 59636-02-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-(n-butyl)benzhydrazide
• 英文别名: Butyl benzhydrazide；2-butylbenzohydrazide
• CAS: 59636-02-1
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: VBGPEGUCOQNWBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  o-(n-butyl)benzhydrazide 反应 3.17h， 生成 3-(2-丁基苯基)-5-苯基-2H-1,2,4-三唑
  参考文献：
  名称：

  A new class of nonhormonal pregnancy-terminating agents. Synthesis and contragestational activity of 3,5-diaryl-s-triazoles

  摘要：

  A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents. The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency. Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained. One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species. A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.

  DOI：

  10.1021/jm00362a018
• 作为产物：
  描述：

  butyl-benzoic acid chloride 在 盐酸 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 o-(n-butyl)benzhydrazide
  参考文献：
  名称：

  A new class of nonhormonal pregnancy-terminating agents. Synthesis and contragestational activity of 3,5-diaryl-s-triazoles

  摘要：

  A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents. The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency. Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained. One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species. A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.

  DOI：

  10.1021/jm00362a018

文献信息

• Microbicidal nitrofuryl compounds
  申请人：Byk Gulden Lomberg Chemische Fabrik GmbH

  公开号：US04051253A1

  公开（公告）日：1977-09-27

  2-[(O-ALKYLAROYLHYDRAZONO)PROPEN-1-YL]-5-NITROFURANS [1] ARE PREPARED BY CONDENSING 3-(5-NITRO-2-FURYL)ACRYLALDEHYDE [2] WITH AN O-ALKYLAROYL HYDRAZIDE [3]. Compounds [1] are bactericides, protozoacides and fungicides and are administrable to animals in therapeutically-acceptable compositions.

  2-[(O-烷基芳酰肼基)丙烯酰基]-5-硝基呋喃[1]是通过将3-(5-硝基-2-呋喃基)丙烯醛[2]与O-烷基芳酰肼[3]缩合而制备的。化合物[1]是杀菌剂、原虫剂和杀真菌剂，并可在治疗上可接受的组合物中给动物使用。
• Polymers for use in optical devices
  申请人：Cambridge Display Technology Limited

  公开号：EP1715020A2

  公开（公告）日：2006-10-25

  A process for the production of an optical device, which process comprises providing a charge transport film-forming solvent processable polymer and cross-linking the solvent processable polymer under conditions so as to increase its molar mass whereby the polymer is made resistant to solvent dissolution.

  一种生产光学器件的工艺，该工艺包括提供电荷传输成膜的可溶剂加工聚合物，并在增加其摩尔质量的条件下交联该可溶剂加工聚合物，从而使该聚合物具有抗溶剂溶解的能力。
• OMODEI-SALE, A.;CONSONNI, P.;GALLIANI, G., J. MED. CHEM., 1983, 26, N 8, 1187-1192
  作者：OMODEI-SALE, A.、CONSONNI, P.、GALLIANI, G.

  DOI：——

  日期：——
• OPTICAL RECORDING MATERIALS HAVING HIGH STORAGE DENSITY
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1639046A2

  公开（公告）日：2006-03-29
• US4051253A
  申请人：——

  公开号：US4051253A

  公开（公告）日：1977-09-27