[(trimethylsilyl)ethynyl]benzaldehyde | 500117-74-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: [(trimethylsilyl)ethynyl]benzaldehyde
• 英文别名: [4-Formyl-2-methoxy-6-(2-trimethylsilylethynyl)phenyl] acetate
• CAS: 500117-74-8
• 化学式: C₁₅H₁₈O₄Si
• 分子量: 290.391
• InChiKey: JYPNEHZFJKKWML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.66
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(trimethylsilyl)ethynyl]benzaldehyde 在 sodium tetrahydroborate 作用下， 生成 4-acetoxy-3-methoxy-5-[(trimethylsilyl)ethynyl]benzenemethanol
  参考文献：
  名称：

  Aliphatic Acetylenic Homocoupling Catalyzed by a Novel Combination of AgOTs−CuCl₂−TMEDA and Its Application for the Solid-Phase Synthesis of Bis-benzo[b]furan-Linked 1,3-Diynes

  摘要：

  A novel catalytic system of AgOTs-CuCl2-TMEDA is described for the homocoupling of aliphatic acetylenes on solid support. It is the first observation that Ag-l's activating triple bond could facilitate Cu-II-mediated oxidative acetylenic homocoupling. This study provides an efficient way to synthesize a diversified symmetrical bis-benzo[b]furan-linked 1,3-diyne library on solid support.

  DOI：

  10.1021/ol030009g
• 作为产物：
  描述：

  5-碘香兰素 在 bis-triphenylphosphine-palladium(II) chloride copper(l) iodide 、 三乙胺 作用下， 生成 [(trimethylsilyl)ethynyl]benzaldehyde
  参考文献：
  名称：

  Aliphatic Acetylenic Homocoupling Catalyzed by a Novel Combination of AgOTs−CuCl₂−TMEDA and Its Application for the Solid-Phase Synthesis of Bis-benzo[b]furan-Linked 1,3-Diynes

  摘要：

  A novel catalytic system of AgOTs-CuCl2-TMEDA is described for the homocoupling of aliphatic acetylenes on solid support. It is the first observation that Ag-l's activating triple bond could facilitate Cu-II-mediated oxidative acetylenic homocoupling. This study provides an efficient way to synthesize a diversified symmetrical bis-benzo[b]furan-linked 1,3-diyne library on solid support.

  DOI：

  10.1021/ol030009g

文献信息

• [EN] BENZO(b)FURAN DIMERS<br/>[FR] DIMERES DE BENZO(B)FURANE
  申请人：VIVOQUEST INC

  公开号：WO2004000764A3

  公开（公告）日：2004-07-08