2,3,5,6-tetrafluoro-4.4’-dimethoxyl-1,1’-biphenyl | 1439371-21-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5,6-tetrafluoro-4.4’-dimethoxyl-1,1’-biphenyl
• 英文别名: 2,3,5,6-tetrafluoro-4,4'-dimethoxybiphenyl
• CAS: 1439371-21-7
• 化学式: C₁₄H₁₀F₄O₂
• 分子量: 286.226
• InChiKey: RDJXLCSIFIDBPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.93
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2,3,5,6-四氟茴香醚 、 (4-甲氧基苯基)三氟硼酸钾 在 palladium diacetate 、 silver(l) oxide 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 15.0h， 以70%的产率得到2,3,5,6-tetrafluoro-4.4’-dimethoxyl-1,1’-biphenyl
  参考文献：
  名称：

  Preparation of fluorinated biaryls through direct palladium-catalyzed coupling of polyfluoroarenes with aryltrifluoroborates

  摘要：

  The direct palladium-catalyzed coupling of polyfluoroarenes with aryltrifluoroborates gave the desired products of fluorinated biaryls in good to excellent yields. A diverse set of important functional groups including methoxy, aldehyde, ester, nitro and halide can be well tolerated in the protocol. (c) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.03.017

文献信息

• Direct palladium-catalyzed desulfitative CC coupling of polyfluoroarenes with arylsulfinate salts: Water-accelerated reactions
  作者：Xiaoxi Lin、Yi You、Zhiqiang Weng

  DOI：10.1016/j.jfluchem.2014.06.017

  日期：2014.9

  A new approach to the synthesis of fluorinated biaryl compounds from easily available starting materials is described. This protocol is based on the direct palladium-catalyzed desulfitative cross-coupling of polyfluoroarenes with various arylsulfinate salts via CH bond activation, accelerated by trace amount of water. The method allows the synthesis of various fluorinated biaryl products in moderate

  描述了一种由容易获得的起始原料合成氟化联芳基化合物的新方法。该协议基于直接钯催化desulfitative交叉偶联以通过C芳基亚各种盐polyfluoroarenes的H键活化，通过水的微量加速。该方法允许的各种氟化二芳基产物的合成在中度至良好的产率，并且耐受多种官能团，包括烷基，苯基，甲氧基，氟和氯基团。
• Palladium-Catalyzed Direct Arylation of Polyfluoroarenes with Organosilicon Reagents
  作者：Huixin Fan、Yaping Shang、Weiping Su

  DOI：10.1002/ejoc.201402091

  日期：2014.6

  The palladium-catalyzed direct arylation of polyfluoroarenes with organosilicon reagents was achieved by establishing general reaction conditions. This protocol was compatible with a broad range of functional groups and offered the desired products in moderate to good yields.

  通过建立一般反应条件，实现了钯催化的多氟芳烃与有机硅试剂的直接芳基化反应。该协议与广泛的官能团兼容，并以中等至良好的产量提供所需的产品。