N-(3-methyl-isothiazol-5-yl)-benzamide | 99984-41-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-methyl-isothiazol-5-yl)-benzamide
• 英文别名: N-(3-Methyl-isothiazol-5-yl)-benzamid；N-(3-methyl-1,2-thiazol-5-yl)benzamide
• CAS: 99984-41-5
• 化学式: C₁₁H₁₀N₂OS
• 分子量: 218.279
• InChiKey: VTLYQLTXHLHMNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF BRUTON'S TYROSINE KINASE
  申请人：Pharmacyclics, LLC

  公开号：EP3174539A1

  公开（公告）日：2017-06-07
• [EN] INHIBITORS OF BRUTON'S TYROSINE KINASE<br/>[FR] INHIBITEURS DE LA TYROSINE KINASE DE BRUTON
  申请人：PHARMACYCLICS LLC

  公开号：WO2016019233A1

  公开（公告）日：2016-02-04

  Disclosed herein are amido compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.