1-(1-Hydroxy-3-methyl-but-2-enyl)-naphthalen-2-ol | 88252-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(1-Hydroxy-3-methyl-but-2-enyl)-naphthalen-2-ol
• 英文别名: 1-(1-Hydroxy-3-methylbut-2-enyl)naphthalen-2-ol；1-(1-hydroxy-3-methylbut-2-enyl)naphthalen-2-ol
• CAS: 88252-75-9
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: VYZKMYXYRGVKRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1-Hydroxy-3-methyl-but-2-enyl)-naphthalen-2-ol 在 phenyltrimethylammonium tribromide 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 生成 1-溴-2-萘酚
  参考文献：
  名称：

  Regioselective C(sp ² )−C(sp ³ ) Oxidative Bond Cleavage of 1‐(1‐Hydroxyalkyl) naphthalen‐2‐ols: First Synthesis of 1‐Azido‐halo‐naphthalene‐2(1 H )‐ones

  摘要：

  AbstractA new one‐pot oxidative cleavage of C(sp2)−C(sp3) bond has been explored using two complementary protocols employing Phenylselenyl bromide (PhSeBr) as well as Phenyltrimethylammonium Tribromide (PTAB), with much greater efficiency and scope. The oxidative cleavage proceeds via a dearomatization step to afford potentially useful bromonaphthols along with corresponding aldehydes. In this course, we also described the first synthesis of synthetically important azido‐halo naphthaleneones.

  DOI：

  10.1002/ijch.202000082
• 作为产物：
  描述：

  3-甲基-2-丁烯醛 、 1-溴-2-萘酚 在 正丁基锂 作用下， 生成 1-(1-Hydroxy-3-methyl-but-2-enyl)-naphthalen-2-ol
  参考文献：
  名称：

  Synthesis of 4- and 6-Substituted 2,2-Dimethyl-2H-chromenes

  摘要：

  DOI：

  10.1055/s-1983-30540

文献信息

• Regioselective C(sp ² )−C(sp ³ ) Oxidative Bond Cleavage of 1‐(1‐Hydroxyalkyl) naphthalen‐2‐ols: First Synthesis of 1‐Azido‐halo‐naphthalene‐2(1 <i>H</i> )‐ones
  作者：Manoj Kumar Ghosh、Barnali Roy、Debayan Sarkar

  DOI：10.1002/ijch.202000082

  日期：2021.5

  AbstractA new one‐pot oxidative cleavage of C(sp2)−C(sp3) bond has been explored using two complementary protocols employing Phenylselenyl bromide (PhSeBr) as well as Phenyltrimethylammonium Tribromide (PTAB), with much greater efficiency and scope. The oxidative cleavage proceeds via a dearomatization step to afford potentially useful bromonaphthols along with corresponding aldehydes. In this course, we also described the first synthesis of synthetically important azido‐halo naphthaleneones.
• Synthesis of 4- and 6-Substituted 2,2-Dimethyl-2<i>H</i>-chromenes
  作者：John J. Talley

  DOI：10.1055/s-1983-30540

  日期：——