N-(1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl)-acetamide | 16124-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl)-acetamide
• 英文别名: N-(1,4-Dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl)-acetamid；N-(1,4-dioxo-2,3-dihydrophthalazin-6-yl)acetamide
• CAS: 16124-00-8
• 化学式: C₁₀H₉N₃O₃
• 分子量: 219.2
• InChiKey: VSKQKQMRSLQWHD-UHFFFAOYSA-N

物化性质

• 密度：
  1.419±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-乙酰基氨基邻苯二甲酸二甲酯 在 一水合肼 作用下， 生成 N-(1,4-dioxo-1,2,3,4-tetrahydro-phthalazin-6-yl)-acetamide
  参考文献：
  名称：

  The Chemiluminescence of Phthalhydrazide Derivatives¹

  摘要：

  DOI：

  10.1021/ja01291a031

文献信息

• Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability
  作者：R. F. Schoeni、V. A. Freedman、R. B. Wallace

  DOI：10.1093/geronb/56.4.s206

  日期：2001.7.1

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.
• The Chemiluminescence of Phthalhydrazide Derivatives¹
  作者：Carl N. Zellner、Gregg Dougherty

  DOI：10.1021/ja01291a031

  日期：1937.12