3-(4-tert-butylphenyl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one | 1334470-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-tert-butylphenyl)-1-(3,5-dimethylpiperidin-1-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one
• CAS: 1334470-45-9
• 化学式: C₂₈H₃₉NO₄
• 分子量: 453.622
• InChiKey: FUDUWFBLNVPRIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• AMIDO COMPOUNDS AS RORYT MODULATORS AND USES THEREOF
  申请人：New York University

  公开号：EP3002008A1

  公开（公告）日：2016-04-06

  Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

  本发明公开了具有下式表示的氨基化合物： 其中 n1、n2、R1a、R1b、R2、R3、R4、R5 和 R6 如本文所述。这些化合物可制备成药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，包括非限制性的炎症、自身免疫性疾病、癌症和移植物抗宿主疾病。
• POLYMERIZABLE COMPOSITIONS CONTAINING (METH)ACRYLATE MONOMERS HAVING SULFIDE LINKAGES
  申请人：PPG Industries Ohio, Inc.

  公开号：EP3838935A2

  公开（公告）日：2021-06-23

  Provided is a polymerizable composition including (meth)acrylate monomers having at least two sulfide (-S-) linkages in the monomer. The polymerizable compositions include a first (meth)acrylate monomer represented by the following Formula (I), where L1 is selected from a multivalent optionally substituted hydrocarbyl group optionally interrupted with at least one of -C(O)-, -S-, -O- and combinations thereof, and a divalent linking group represented by the following Formula (A). In Formula (A), Y is O or S. Also in Formula (I), L2 is independently for each n a divalent optionally substituted hydrocarbyl group optionally interrupted with at least one of -O- and -S-, R1 is independently selected for each n from hydrogen and methyl, and n is from 2 to 6. The polymerizable compositions also may include a polymerization moderator. Also provided are polymerizates including photochromic articles and optical elements prepared from such polymerizable compositions.

  本发明提供了一种可聚合组合物，包括在单体中具有至少两个硫化物（-S-）连接的（甲基）丙烯酸酯单体。可聚合组合物包括由下式（I）代表的第一种（甲基）丙烯酸酯单体、 其中 L1 选自至少用-C(O)-、-S-、-O-及其组合中的一种任选间断的多价任选取代的烃基，以及由下式(A)表示的二价连接基团。 在式 (A) 中，Y 是 O 或 S。同样在式 (I) 中，L2 对于每个 n 独立地是二价任选取代的烃基，任选被 -O- 和 -S- 中的至少一种打断，R1 对于每个 n 独立地选自氢和甲基，n 是 2 到 6。可聚合组合物还可包括聚合调节剂。此外，还提供了聚合物，包括光致变色物品和由此类可聚合组合物制备的光学元件。
• Amido compounds as RORγt modulators and uses thereof
  申请人：New York University

  公开号：US10561666B2

  公开（公告）日：2020-02-18

  Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

  本发明公开了具有下式表示的氨基化合物： 其中 n1、n2、R1a、R1b、R2、R3、R4、R5 和 R6 如本文所述。这些化合物可制备成药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，包括非限制性的炎症、自身免疫性疾病、癌症和移植物抗宿主疾病。
• AMIDO COMPOUNDS AS RORyt MODULATORS AND USES THEREOF
  申请人：New York University

  公开号：EP2558087A1

  公开（公告）日：2013-02-20
• AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF
  申请人：Littman Dan

  公开号：US20130085162A1

  公开（公告）日：2013-04-04

  Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R 1a , R 1b , R 2 , R 3 , R 4 , R 5 , and R 6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.