2,3,5-trimethyl-p-phenylenediamine | 4734-73-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5-trimethyl-p-phenylenediamine
• 英文别名: 2,3,5-Trimethyl-p-phenylendiamin；2.3.5-Trimethyl-phenylendiamin-(1.4)；3.6-Diamino-1.2.4-trimethyl-benzol；3.6-Diamino-pseudocumol；2,3,5-Trimethylbenzene-1,4-diamine
• CAS: 4734-73-0
• 化学式: C₉H₁₄N₂
• mdl: MFCD20693612
• 分子量: 150.224
• InChiKey: IFUXXUAAJBKDGO-UHFFFAOYSA-N

物化性质

• 熔点：
  71-72 °C
• 沸点：
  296.5±35.0 °C(Predicted)
• 密度：
  1.051±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

制备方法与用途

用途：维生素E醋酸盐的中间体。

生产方法：首先用1,2,4-三甲苯通过硫酸磺化生成2,4,5-三甲基苯磺酸，随后进行硝化反应得到2,4,5-三甲基-3,6-二硝基苯磺酸。最后，使用盐酸和金属锡还原该化合物，即可制得目标产物。

反应信息

• 作为产物：
  描述：

  1-bromo-2,4,5-trimethyl-3,6-dinitro-benzene 在 甲醇 、 镍 作用下， 140.0 ℃ 、15.69 MPa 条件下， 生成 2,3,5-trimethyl-p-phenylenediamine
  参考文献：
  名称：

  Grinberg; Swischtschuk, Ukrainskij Khimicheskij Zhurnal, 1957, vol. 23, p. 79

  摘要：

  DOI：

文献信息

• [EN] CATIONIC PARA-PHENYLENEDIAMINES, COMPOSITION COMPRISING AT LEAST SUCH COMPOUNDS, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF<br/>[FR] PARAPHÉNYLÈNEDIAMINES CATIONIQUES, COMPOSITION COMPRENANT AU MOINS DE TELS COMPOSÉS, PROCÉDÉ DE MISE EN OEUVRE ET UTILISATION
  申请人：OREAL

  公开号：WO2013087934A1

  公开（公告）日：2013-06-20

  The present invention relates to particular cationic paraphenylenediamine compounds of formula (I) below and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair. The invention also relates to a dye composition comprising, in a suitable dyeing medium, one or more cationic para-phenylenediamines as defined previously. Finally, the invention relates to a dyeing device using the said composition.

  本发明涉及以下式（I）的特定阳离子对苯二胺化合物，以及其用于染色角蛋白纤维，特别是人类角蛋白纤维如头发的用途。该发明还涉及一种染料组合物，其中在适当的染料介质中包含一个或多个如前所定义的阳离子对苯二胺。最后，该发明涉及使用所述组合物的染色装置。
• [EN] PARTICULAR AZOMETHINE DIRECT DYES, DYE COMPOSITION COMPRISING AT LEAST ONE SUCH COMPOUND, IMPLEMENTATION PROCESS THEREFORE AND USE THEREOF<br/>[FR] COLORANTS DIRECTS SPÉCIFIQUES D'AZOMÉTHINE, COMPOSITION DE COLORANT COMPRENANT AU MOINS L'UN DE CES COMPOSÉS, LEUR PROCÉDÉ DE MISE EN OEUVRE ET LEUR UTILISATION
  申请人：OREAL

  公开号：WO2013087636A1

  公开（公告）日：2013-06-20

  The present invention relates to direct dyes of azomethine type of formula (I) below; and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair. The invention also relates to a composition for dyeing keratin fibres, comprising such direct dyes in a suitable dyeing medium. Similarly, a subject of the invention is a process for dyeing keratin fibres using the said dye composition, and also a device comprising the same. Finally, the present invention also relates to precursors of these direct dyes.

  本发明涉及以下式(I)的偶氮亚甲基型直接染料；以及其用于染色角蛋白纤维，特别是人类角蛋白纤维如头发的用途。该发明还涉及一种用于染色角蛋白纤维的组合物，包括适当的染色介质中的这种直接染料。同样，本发明的一个对象是使用所述染料组合物染色角蛋白纤维的方法，以及包括相同的设备。最后，本发明还涉及这些直接染料的前体。
• [EN] CATIONIC TETRAHYDROPYRAZOLOPYRIDINES, DYE COMPOSITION COMPRISING SUCH OXIDATION BASES, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF<br/>[FR] TÉTRAHYDROPYRAZOLOPYRIDINES CATIONIQUES, COMPOSITION DE COLORANT COMPRENANT DE TELLES BASES D'OXYDATION, LEUR PROCÉDÉ DE MISE EN OEUVRE ET LEUR UTILISATION
  申请人：OREAL

  公开号：WO2013087933A1

  公开（公告）日：2013-06-20

  The present invention relates to particular cationic tetrahydropyrazolopyridine compounds of formula (I) below and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair. The invention also relates to a dye composition comprising, in a suitable dyeing medium, one or more cationic tetrahydropyrazolopyridines as defined previously. Finally, the invention relates to a dyeing device using the said composition.

  本发明涉及特定的阳离子四氢吡唑吡啶化合物（I）以及其在染色角蛋白纤维，特别是人类角蛋白纤维，如头发中的使用。本发明还涉及一种染料组合物，其中在适当的染料介质中，包含一种或多种如上所定义的阳离子四氢吡唑吡啶。最后，本发明涉及使用该组合物的染色装置。
• [EN] COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING AT LEAST ONE CATIONIC DIAMINO-N,N-DIHYDROPYRAZOLONE DERIVATIVE<br/>[FR] COMPOSITION POUR LA COLORATION DE FIBRES DE KÉRATINE COMPRENANT AU MOINS UN DÉRIVÉ DE DIAMINO-N,N-DIHYDROPYRAZOLONE CATIONIQUE
  申请人：OREAL

  公开号：WO2009098257A1

  公开（公告）日：2009-08-13

  One subject of the invention ia a composition for dyeing keratin fibres, and in particular human keratin fibres such as hair, comprising at least one cationic diamino-N, N-dihydropyrazolone derivative of formula (I) as an oxidation base and a method using it. Similarly, one subject is cationic amino-N,N- dihydropyrazolone derivatives or an addition salt thereof. The present invention makes it possible in particular to obtain a colouring of keratin fibres which is persistent, resistant to light and resistant to washing.

  本发明的一个主题是一种用于染色角蛋白纤维，特别是人类角蛋白纤维（如头发）的组合物，其中包括至少一种式（I）的阳离子二氨基-N，N-二氢吡唑酮衍生物作为氧化基，并使用该方法。同样，一个主题是阳离子氨基-N，N-二氢吡唑酮衍生物或其加成盐。本发明特别可以获得一种持久的、耐光的和耐洗的角蛋白纤维染色。
• METHOD OF TREATING BRAIN CANCER
  申请人：Cai Sui Xiong

  公开号：US20080051398A1

  公开（公告）日：2008-02-28

  Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to the use of these compounds in treating brain cancer.

  本发明涉及4-芳基氨基喹唑啉及其类似物，其有效激活caspases并诱导细胞凋亡。本发明的化合物可用于治疗各种临床病症，其中发生异常细胞的不受控制的生长和扩散，特别是用于治疗脑癌。