1,4-bis(2-((S)-4-benzyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phthalazine | 1301726-35-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,4-bis(2-((S)-4-benzyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phthalazine
• 英文别名: (4S)-4-benzyl-2-[2-[4-[2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]propan-2-yl]phthalazin-1-yl]propan-2-yl]-4,5-dihydro-1,3-oxazole
• CAS: 1301726-35-1
• 化学式: C₃₄H₃₆N₄O₂
• 分子量: 532.685
• InChiKey: JOBQZSFZSCRRGF-UIOOFZCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  69
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,4-二氯酞嗪 在 zinc(II) chloride 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 氯苯 为溶剂， 反应 99.0h， 生成 1,4-bis(2-((S)-4-benzyl-4,5-dihydrooxazol-2-yl)propan-2-yl)phthalazine
  参考文献：
  名称：

  Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones

  摘要：

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.02.098

文献信息

• Chiral dinuclear phthalazine bridged bisoxazoline ligands: synthesis and application in enantioselective Cu-catalyzed conjugate addition of ZnEt2 to enones
  作者：Liang Zhang、Guoqiang Yang、Chaoren Shen、Sabah Arghib、Wanbin Zhang

  DOI：10.1016/j.tetlet.2011.02.098

  日期：2011.5

  A new class of chiral dinuclear ligands with phthalazine bridged bisoxazoline scaffold was designed and prepared in convenient synthetic routes. H-1 NMR analysis showed that this class of ligands could coordinate with two metal ions, either same or different. These ligands afforded good to excellent yields and enantioselectivities in Cu-catalyzed conjugate addition of ZnEt2 to enones. (C) 2011 Elsevier Ltd. All rights reserved.