N-[5-(2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl)-2-fluorophenyl]-2-(1,3-benzodioxol-5-yl)acetamide | 935988-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: N-[5-(2-amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl)-2-fluorophenyl]-2-(1,3-benzodioxol-5-yl)acetamide
• CAS: 935988-10-6
• 化学式: C₂₀H₂₀FN₃O₃S
• 分子量: 401.462
• InChiKey: SYNBNMPQBCAPGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• AMINODIHYDROTHIAZINE DERIVATIVES
  申请人：Kobayashi Naotake

  公开号：US20090082560A1

  公开（公告）日：2009-03-26

  A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl; R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R 5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
• PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE
  申请人：Kobayashi Naotake

  公开号：US20100160290A1

  公开（公告）日：2010-06-24

  A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl; R 2a , R 2b , R 3a , R 3b , R 4a and R 4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R 5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
• US8173642B2
  申请人：——

  公开号：US8173642B2

  公开（公告）日：2012-05-08
• US8546380B2
  申请人：——

  公开号：US8546380B2

  公开（公告）日：2013-10-01
• US8633188B2
  申请人：——

  公开号：US8633188B2

  公开（公告）日：2014-01-21