S-(1,4-naphthoquinon-2-yl)mercaptoacetic acid | 57414-03-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: S-(1,4-naphthoquinon-2-yl)mercaptoacetic acid
• 英文别名: S-(1,4-naphthoquino-2-yl)mercaptoacetic acid；(1,4-dioxo-1,4-dihydro-[2]naphthylsulfanyl)-acetic acid；(1,4-Dioxo-1,4-dihydro-[2]naphthylmercapto)-essigsaeure；Acetic acid, [(1,4-dihydro-1,4-dioxo-2-naphthalenyl)thio]-；2-(1,4-dioxonaphthalen-2-yl)sulfanylacetic acid
• CAS: 57414-03-6
• 化学式: C₁₂H₈O₄S
• 分子量: 248.259
• InChiKey: JSXVNSXLESSQMA-UHFFFAOYSA-N

物化性质

• 熔点：
  172 °C(Solv: water (7732-18-5))
• 沸点：
  464.8±45.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  96.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  S-(1,4-naphthoquinon-2-yl)mercaptoacetic acid 在 PPA 、 Polyphosphoric acid (PPA) 作用下， 反应 1.0h， 以25%的产率得到2,3,4,9-tetrhydronaphtho<2,3-b>thiophene-3,4,9-trione
  参考文献：
  名称：

  Tandon, V. K.; Vaish, Meenu; Khan, Z. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1993, vol. 32, # 4, p. 445 - 448

  摘要：

  DOI：
• 作为产物：
  描述：

  巯基乙酸 、 1,4-萘醌 在 溶剂黄146 作用下， 生成 S-(1,4-naphthoquinon-2-yl)mercaptoacetic acid
  参考文献：
  名称：

  Miyaki; Ikeda, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1954, vol. 74, p. 655

  摘要：

  DOI：

文献信息

• Electrochemical test device
  申请人：Inside Biometrics Limited

  公开号：US10371617B2

  公开（公告）日：2019-08-06

  An electrochemical test device for determining a concentration of one or more analytes in a fluid sample is provided. The electrochemical test device comprises a set of electrodes including two or more working electrodes, each working electrode for determining the concentration of a corresponding analyte, and sensing chemistry for each working electrode, wherein the sensing chemistry for a first of the two or more working electrodes comprises a diaphorase, an electron transfer agent, an NAD(P)+-dependent dehydrogenase and a cofactor for the NAD(P)+-dependent dehydrogenase, wherein at least some of the diaphorase for the first working electrode is disposed in a diaphorase-containing layer which extends over the first working electrode and at least a second of the two or more working electrodes.

  提供了一种用于确定流体样品中一种或多种分析物浓度的电化学测试装置。该电化学测试装置包括一组电极，其中包括两个或多个工作电极，每个工作电极用于确定相应分析物的浓度，以及每个工作电极的传感化学试剂，其中两个或多个工作电极中第一个工作电极的传感化学试剂包括二磷酸酶、电子传递剂、NAD(P)+ 依赖性脱氢酶和 NAD(P)+ 依赖性脱氢酶的辅助因子、电子转移剂、NAD(P)+ 依赖性脱氢酶和 NAD(P)+依赖性脱氢酶的辅助因子，其中用于第一工作电极的至少部分二磷酸盐酶设置在含二磷酸盐酶层中，该层延伸至第一工作电极和两个或多个工作电极中的至少一个第二电极上。
• Tandon, V K; Vaish, Meenu; Jain, Sudha, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1992, vol. 31, # 1, p. 53 - 54
  作者：Tandon, V K、Vaish, Meenu、Jain, Sudha

  DOI：——

  日期：——
• Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents
  作者：Vishnu K. Tandon、Dharmendra B. Yadav、Ravindra V. Singh、Meenu Vaish、Ashok K. Chaturvedi、Praveen K. Shukla

  DOI：10.1016/j.bmcl.2005.04.075

  日期：2005.7

  A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for antibacterial and antiviral activities. The structure-activity relationships of these compounds were also studied. The results suggest that compounds 9-22 showed in vitro marked antibacterial activity. Compounds 4c and 7a showed inhibitory effect against RNA dependent RNA polymerase induced poliovirus type 2 infected HeLa cells. (c) 2005 Elsevier Ltd. All rights reserved.
• Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents
  作者：Vishnu K. Tandon、Rakeshwar B. Chhor、Ravindra V. Singh、Sanjay Rai、Dharmendra B. Yadav

  DOI：10.1016/j.bmcl.2004.01.002

  日期：2004.3

  A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal proifile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus. (C) 2004 Elsevier Ltd. All rights reserved.
• ELECTROCHEMICAL TEST DEVICE
  申请人：Inside Biometrics Limited

  公开号：EP3289343A1

  公开（公告）日：2018-03-07