N-tert-butyl-2-(2-(2-methoxy-4-morpholinophenylamino)-5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide | 1384860-49-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-tert-butyl-2-(2-(2-methoxy-4-morpholinophenylamino)-5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzenesulfonamide
• 英文别名: N-tert-butyl-2-[[2-(2-methoxy-4-morpholin-4-ylanilino)-5,5-dimethyl-6,7-dihydropyrrolo[2,3-d]pyrimidin-4-yl]amino]benzenesulfonamide
• CAS: 1384860-49-4
• 化学式: C₂₉H₃₉N₇O₄S
• 分子量: 581.739
• InChiKey: UGYDPMYHPIGTSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS
  申请人：Xiao Dengming

  公开号：US20130281438A1

  公开（公告）日：2013-10-24

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.

  本发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物和化合物用于抑制FAK和/或Pyk2以及治疗FAK和/或Pyk2介导的疾病或疾病的方法。
• Aqueous soluble ferrimagnets stabilized by block copolymers
  申请人：Bajjuri Krishna M.

  公开号：US10738174B2

  公开（公告）日：2020-08-11

  The present invention relates to a water-soluble polymer complex that includes a water-soluble block copolymer and a magnetic nanoparticle, wherein the water-soluble polymer complex has a nonzero net magnetic moment in the absence of an applied magnetic field at ambient temperatures. The water-soluble block copolymer is preferably a diblock or triblock copolymer and the magnetic nanoparticle is preferably a ferrimagnetic or ferromagnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules. Exemplary water-soluble polymer complexes covered under the scope of the invention include PEG112-b-PAA40 modified CoFe2O4; NH2-PEG112-b-PAA40 modified CoFe2O4; PNIPAM68-b-PAA28 modified CoFe2O4; and mPEG-b-PCL-b-PAA modified CoFe2O4.

  本发明涉及一种包括水溶性嵌段共聚物和磁性纳米粒子的水溶性聚合物复合物，其中水溶性聚合物复合物在环境温度下无外加磁场时具有非零净磁矩。水溶性嵌段共聚物最好是二嵌段或三嵌段共聚物，磁性纳米粒子最好是铁磁性或铁磁性纳米粒子。水溶性复合物可以用活性基团衍生并与生物大分子共轭。本发明范围内的示例性水溶性聚合物复合物包括 PEG112-b-PAA40 改性 CoFe2O4；NH2-PEG112-b-PAA40 改性 ；PNIPAM68-b-PAA28 改性 ；以及 mPEG-b-PCL-b-PAA 改性 。
• AQUEOUS SOLUBLE FERRIMAGNETS STABILIZED BY BLOCK COPOLYMERS
  申请人：Bajjuri Krishna M.

  公开号：US20130281623A1

  公开（公告）日：2013-10-24

  The present invention relates to a water-soluble polymer complex that includes a water-soluble block copolymer and a magnetic nanoparticle, wherein the water-soluble polymer complex has a nonzero net magnetic moment in the absence of an applied magnetic field at ambient temperatures. The water-soluble block copolymer is preferably a diblock or triblock copolymer and the magnetic nanoparticle is preferably a ferrimagnetic or ferromagnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules. Exemplary water-soluble polymer complexes covered under the scope of the invention include PEG 112 -b-PAA 40 modified CoFe 2 O 4 ; NH 2 -PEG 112 -b-PAA 40 modified CoFe 2 O 4 ; PNIPAM 68 -b-PAA 28 modified CoFe 2 O 4 ; and mPEG-b-PCL-b-PAA modified CoFe 2 O 4 .
• US9428508B2
  申请人：——

  公开号：US9428508B2

  公开（公告）日：2016-08-30