dimethyl (S)-3-t-butoxycarbonylamino-5-[2-chloro-4-(2-methoxymethoxy-5-trifluoromethylphenylthio)phenyl]-3-propylpentylphosphonate | 1260512-84-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: dimethyl (S)-3-t-butoxycarbonylamino-5-[2-chloro-4-(2-methoxymethoxy-5-trifluoromethylphenylthio)phenyl]-3-propylpentylphosphonate
• 英文别名: tert-butyl N-[(3S)-1-[2-chloro-4-[2-(methoxymethoxy)-5-(trifluoromethyl)phenyl]sulfanylphenyl]-3-(2-dimethoxyphosphorylethyl)hexan-3-yl]carbamate
• CAS: 1260512-84-2
• 化学式: C₃₀H₄₂ClF₃NO₇PS
• 分子量: 684.154
• InChiKey: KHIIPTCKFAYMBZ-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  44
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• DIPHENYL SULFIDE DERIVATIVES AND MEDICINES CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：Kohno Yasushi

  公开号：US20120101068A1

  公开（公告）日：2012-04-26

  Provided are diphenyl sulfide derivatives which have excellent S1P3 antagonistic activity and are useful as drugs. Intensive studies have been made for the purpose of creating a compound having S1P3 antagonistic activity. As a result of the intensive studies, it has been found that diphenyl sulfide derivatives represented by general formula (1) have excellent S1P3 antagonistic activity. In general formula (1), R 1 is a hydrogen atom or the like; R 2 is an optionally substituted alkyl group having 1 to 6 carbon atoms, or the like; X is a methylene group which may be substituted with one or two fluorine atoms, or the like; Y is a hydrogen atom or the like; and Z is a halogen atom.

  提供了具有优异S1P3拮抗活性并且可用作药物的二苯基硫醚衍生物。为了创造具有S1P3拮抗活性的化合物，进行了深入研究。经过深入研究，发现由通式（1）表示的二苯基硫醚衍生物具有优异的S1P3拮抗活性。在通式（1）中，R1是氢原子或类似物；R2是具有1至6个碳原子的可选择取代的烷基基团或类似物；X是一个甲基基团，可能被一个或两个氟原子取代，或类似物；Y是氢原子或类似物；Z是卤素原子。
• CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
  申请人：Cheng Jianjun

  公开号：US20120178711A1

  公开（公告）日：2012-07-12

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及含有治疗环糊精的聚合物化合物的新型组合物，其设计为小分子治疗药物的载体，以及其制药组合物。这些含有环糊精的聚合物可以提高药物的稳定性和溶解度，并在体内使用时减少小分子治疗药物的毒性。此外，通过从各种连接基团和靶向配体中进行选择，这些聚合物还提供了治疗剂的受控释放方法。本发明还涉及使用上述治疗组合物治疗受试者的方法。本发明还涉及进行制药业务的方法，包括制造、许可或分发包含或涉及上述聚合物化合物的试剂盒。
• US8569270B2
  申请人：——

  公开号：US8569270B2

  公开（公告）日：2013-10-29