4-氨基-2-羟基苯甲酸丙酯 | 6018-20-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-2-羟基苯甲酸丙酯
• 英文名称: 4-amino-2-hydroxy-benzoic acid propyl ester
• 英文别名: 4-Amino-2-hydroxy-benzoesaeure-propylester；4-Aminosalicylsaeure-n-propylester；4-Amino-salicylsaeure-propylester；n-Propyl-4-aminosalicylat；Propyl 4-amino-2-hydroxybenzoate
• CAS: 6018-20-8
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: BGAFTBFFBLVMCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-氨基-2-羟基苯甲酸丙酯 在 吡啶 、 苯 作用下， 生成 4-benzoylamino-2-hydroxy-benzoic acid propyl ester
  参考文献：
  名称：

  Clauder et al., 1949, vol. 4, p. 596,600

  摘要：

  DOI：
• 作为产物：
  描述：

  2-hydroxy-4-nitro-benzoic acid propyl ester 在 乙醇 、 铂 作用下， 生成 4-氨基-2-羟基苯甲酸丙酯
  参考文献：
  名称：

  Jensen; Rosdahl; Ingvorsen, Acta Chemica Scandinavica (1947), 1948, vol. 2, p. 220,222

  摘要：

  DOI：

文献信息

• Enzymatic method for textile dyeing
  申请人：Novozymes A/S

  公开号：US20010037532A1

  公开（公告）日：2001-11-08

  The present invention relates to methods of dyeing a material which involve contacting the material with a dyeing system which comprises: (a) a mixture of (i) an aromatic diamine and (ii) one or more of a naphthol and an aminonaphthalene and (b) an oxidation system comprising (i) a hydrogen peroxide source and an enzyme exhibiting peroxidase activity or (ii) an enzyme exibiting oxidase activity on one or more of the compounds of mixture (a). The material may be a fabric, yarn, fiber, garment or film made of fur, hide, leather, silk or wool, or made of cationic polysaccharide, cotton, diacetate, flax, linen, lyocel, polyacrylic, synthetic polyamide, polyester, ramie, rayon, triacetate, or viscose.

  本发明涉及一种染色材料的方法，其中涉及将材料与染色系统接触，该染色系统包括：（a）芳香族二胺和萘酚和/或氨基萘之一或多种的混合物；以及（b）氧化系统，其中包括（i）过氧化氢源和表现出过氧化酶活性的酶或（ii）在混合物（a）中的一种或多种化合物上表现出氧化酶活性的酶。该材料可以是毛皮、兽皮、皮革、丝绸或羊毛制成的织物、纱线、纤维、服装或薄膜，或是阳离子多糖、棉、醋酸二乙酯、亚麻、亚麻布、莱赛尔、聚丙烯酸、合成聚酰胺、聚酯、苎麻、人造丝或粘胶制成的织物、纱线、纤维、服装或薄膜。
• Hybridization Approach Toward Novel Antituberculars: Design, Synthesis, and Biological Evaluation of Compounds Combining Pyrazinamide and 4-Aminosalicylic Acid
  作者：Ghada Bouz、Petr Šlechta、Ondřej Jand’ourek、Klára Konečná、Pavla Paterová、Pavel Bárta、Martin Novák、Radim Kučera、Nils-Jørgen Knudsen Dal、Federico Fenaroli、Júlia Zemanová、Martin Forbak、Jana Korduláková、Oto Pavliš、Pavla Kubíčková、Martin Doležal、Jan Zitko

  DOI：10.1021/acsinfecdis.2c00433

  日期：2023.1.13

  molecular dynamics identified a viable binding mode of compound 11 in mycobacterial DHFR. The lactone 11′ opens in human plasma to its parent compound 11 (t1/2 = 21.4 min). Compound 11 was metabolized by human liver fraction by slow hydrolysis of the amidic bond (t1/2 = 187 min) to yield PAS and its starting 6-chloropyrazinoic acid. The long t1/2 of compound 11 overcomes the main drawback of PAS (short t1/2

  据世界卫生组织称，除 SARS-CoV-2 病毒外，结核病仍然是单一传染源导致死亡的主要原因。作为我们长期研究的一部分，我们制备了一系列结合一线抗结核药物吡嗪酰胺和二线药物4-氨基水杨酸（PAS）的杂化化合物。化合物11被发现是最有效的，具有广谱的抗分枝杆菌活性，并且相对于其他病原体对分枝杆菌菌株具有选择性。它还保留了其针对多重耐药分枝杆菌菌株的体外活性。尝试了几种结构修饰来提高体外抗分枝杆菌活性。化合物11 ( 11' )的δ-内酯形式对结核分枝杆菌H37Rv具有更有效的体外抗分枝杆菌活性。化合物11进行了体内研究，在大蜡螟和斑马鱼模型中被证明是无毒的，并且它减少了小鼠结核病模型中脾脏中集落形成单位的数量。生化研究表明，化合物11靶向分枝杆菌二氢叶酸还原酶 (DHFR)。计算机对接研究与分子动力学相结合，确定了化合物11在分枝杆菌 DHFR 中的可行结合模式。内酯11'在人血浆中打开生成其母体化合物11（t
• DYEING AGENT AND USE FOR SAME
  申请人：Amano Enzyme Inc.

  公开号：EP2708223A1

  公开（公告）日：2014-03-19

  The object is to provide a process for dyeing that can provide an excellent dyeing effect while utilizing an oxidase, and a dyeing agent for use in the process. Provided is a dyeing agent comprising a modified enzyme obtained by adding positive charge by a chemical modification with an amine to an enzyme selected from the group consisting of an enzyme specified as EC 1.10.3.1, an enzyme specified as EC 1.10.3.2, an enzyme specified as EC 1.3.3.5, an enzyme specified as EC 1.10.3.4, an enzyme specified as EC 1.10.3.3 and an enzyme specified as EC 1.14.18.1. A process for dyeing using the dyeing agent is also provided.

  本发明的目的是提供一种在利用氧化酶的同时能够提供出色染色效果的染色工艺，以及一种用于该工艺的染色剂。本发明提供了一种染色剂，该染色剂包含一种改性酶，该改性酶是通过对选自 EC 1.10.3.1 酶、EC 1.10.3.2 酶、EC 1.3.3.5 酶、EC 1.10.3.4 酶、EC 1.10.3.3 酶和 EC 1.14.18.1 酶组的酶进行胺化学改性而获得正电荷。还提供了一种使用染色剂进行染色的工艺。
• Biotransformation of biologically active compounds made of various classes of chemical substance by means of laccase and manganese peroxidase enzymes
  申请人：——

  公开号：US20030180893A1

  公开（公告）日：2003-09-25

  A process for the preparation of biologically active compounds, wherein active substances having additional functional groups and a modified spectrum of activity and modified application properties are obtainable from medicinal substances and plant protective agents as substrates which bear at least one amino or hydroxy functional group by using a one-electron reaction catalyzed by enzymes or compositions having enzymatic activity and a broad spectrum of substrates, characterized in that free-radical forming enzymes are employed as enzymes and/or supernatants of ligninolytic fungi in solution are employed as compositions having enzymatic activity, wherein the following can be introduced as additional functional groups: A) polyfunctional synthones which provide the active substance with an altered dissolving behavior in aqueous and lipophilic systems and a high interfacial activity; B) aromatic molecules, heteroaromatic compounds; C) heterocyclic compounds; D) active substances having an independent biological activity; E) active substances combining an independent activity and surfactant properties in one molecule; which yield coupling products being covalently linked with the starting materials and having an altered partition behavior which enable polyfunctional interactions with the target organism.

  一种制备生物活性化合物的工艺，其中通过使用具有酶活性和广谱底物的酶或组合物催化的一电子反应，可从作为底物的药用物质和植物保护剂中获得具有附加官能团、改良活性谱和改良应用特性的活性物质，这些底物至少带有一个氨基或羟基官能团、其特征在于采用自由基形成酶作为酶和/或采用溶液中的木质素分解真菌的上清液作为具有酶活性的组合物，其中可引入以下作为附加官能团： A) 多官能团合成物，可使活性物质在水性和亲油性体系中的溶解行为发生改变，并具有较高的界面活性； B) 芳香族分子、杂芳香族化合物； C) 杂环化合物 D) 具有独立生物活性的活性物质； E) 在一个分子中结合了独立活性和表面活性剂特性的活性物质； 它们产生的偶联产物与起始材料共价连接，并具有改变的分配行为，能与目标生物体发生多官能相互作用。
• Stabiliser for radiopharmaceuticals
  申请人：Storey E. Anthony

  公开号：US20050063902A1

  公开（公告）日：2005-03-24

  The present invention provides an improved stabiliser for radiopharmaceuticals which inhibits impurities from being produced by two kinds of decomposition mechanisms and exhibits such an effect that the shelf life of a radiopharmaceutical after its preparation is prolonged as compared with conventional ones. The improvement comprises a combination of an amino-substituted aromatic carboxylic acid or its salt, ester or amide in combination with a diphosphonic acid or its salt.

  本发明提供了一种改进的放射性药物稳定剂，该稳定剂可抑制两种分解机制产生的杂质，与传统稳定剂相比，可延长放射性药物制备后的保质期。这种改进包括氨基取代的芳香族羧酸或其盐、酯或酰胺与二膦酸或其盐的组合。