2-Ethyl-5-methyl-pyrrolidin | 89854-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-Ethyl-5-methyl-pyrrolidin
• 英文别名: 2-ethyl-5-methyl-pyrrolidine；2-Ethyl-5-methylpyrrolidine
• CAS: 89854-80-8
• 化学式: C₇H₁₅N
• mdl: MFCD19159808
• 分子量: 113.203
• InChiKey: HFSPXKKJTJCBNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Novel Substituted Azetidinones
  申请人：Pfefferkorn Jeffrey A.

  公开号：US20080227974A1

  公开（公告）日：2008-09-18

  Novel azetidinones and pharmaceutical compositions are described, as are the methods of using such compounds and compositions to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis.

  本发明涉及一种新型的氮杂环丙酮类化合物及其药用组合物，以及使用此类化合物和组合物治疗高脂血症、高胆固醇血症、高甘油三酯血症和动脉粥样硬化等疾病的方法，包括治疗人类。
• Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
  申请人：Pfizer Limited

  公开号：EP0073663A2

  公开（公告）日：1983-03-09

  Compounds of the formufa: wherein R1, which is attached to a carbon atom of ring "B", is hydrogen, halo, C,-C, alkyl, or -S(C1-C4 alkyl); Y. which is attached to ring "A", is -CN, -COOH, -COO(C1-C4 aikyl) or -CONH2: X is O, S. NH, N(C,-C, alkyl) or -CH=CH; and R. which is attached to a carbon atom of ring "8", is a group of the formula: where Z is -CH2-, -CH=CH-, -OCH2-, -CO- or -S-: and the pharmaceuticaliv. acceptable salts thereof. The compounds in which Y is -COOH, -CCO(C1-C4 alkyl) and -CONH2 are pharmaceutical agents being selective thromboxane synthetase inhibitors. Those in which Y is -CN are useful intermediates.

  形式的化合物： 其中 与环 "B "的碳原子相连的 R1 是氢、卤素、C、-C、烷基或-S(C1-C4 烷基)； 与环 "A "相连的 Y 是-CN、-COOH、-COO(C1-C4 烷基)或-CONH2： X 是 O、S、NH、N(C,-C, 烷基)或-CH=CH；以及 与环 "8 "的碳原子相连的 R 是式中的基团： 其中 Z 是-CH2-、-CH=CH-、-O -、-CO- 或-S-：及其可接受的药用盐。 Y 为-COOH、-CCO(C1-C4 烷基)和-CONH2 的化合物是选择性血栓素合成酶抑制剂。Y 为-CN 的化合物是有用的中间体。
• VASOPRESSIN ANTAGONIST AND OXYTOCIN ANTAGONIST
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0620003A1

  公开（公告）日：1994-10-19

  A benzazepine compound represented by formulae (I) or (II) or a salt thereof, and a vasopressin antagonist or an oxytocin antagonist containing the above compound as the active ingredient.

  由式（I）或（II）代表的苯并氮杂卓化合物或其盐，以及含有上述化合物作为活性成分的血管加压素拮抗剂或催产素拮抗剂。
• Vasopressin antagonist and oxytocin antagonist
  申请人：Otsuka Pharmaceutical Company, Limited

  公开号：EP1902717A2

  公开（公告）日：2008-03-26

  An object of the present invention is to provide a vasopressin antagonist and oxytocin antagonist. The vasopressing antagonist and oxytocin antagonist according to the present invention contain, as the active ingredient, a benzoheterocyclic compound represented by the general formula (1): (wherein R1, R2, R3, R4, R5 and the carbon-carbon bond between 4- and 5-positions in the benzoazepine skeleton are the same as defined in Claims 1 and 2) or salt thereof.

  本发明的目的是提供一种血管加压素拮抗剂和催产素拮抗剂。 根据本发明，血管加压素拮抗剂和催产素拮抗剂含有通式（1）所代表的苯并杂环化合物作为活性成分： (其中 R1、R2、R3、R4、R5 和苯并氮杂卓骨架中 4 位和 5 位之间的碳-碳键与权利要求 1 和 2 中定义的相同）或其盐。
• NOVEL SUBSTITUTED AZETIDINONES
  申请人：Warner-Lambert Company LLC

  公开号：EP1912937A1

  公开（公告）日：2008-04-23