4-chlorophenylcarboxylic acid [4-(2-diethylamino-ethylcarbamoyl)-5-methoxy-phenyl]-amide | 1214283-56-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chlorophenylcarboxylic acid [4-(2-diethylamino-ethylcarbamoyl)-5-methoxy-phenyl]-amide
• 英文别名: 4-[(4-chlorobenzoyl)amino]-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
• CAS: 1214283-56-3
• 化学式: C₂₁H₂₆ClN₃O₃
• 分子量: 403.909
• InChiKey: MKOBVYLFZFIATI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  70.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Pharmaceutical Composition Of A Radioiodinated Benzamide Derivative And Methods Of Making Same
  申请人：Chen Jianqing

  公开号：US20110206608A1

  公开（公告）日：2011-08-25

  Provided is a pharmaceutical composition comprising radioiodinated N-(2-(diethylamino)ethyl)-4-(4-fluorobenzamido)-5-iodo-2-methoxybenzamide of Formula I. The pharmaceutical composition provides a stable formulation for both storing and administering to patients having melanoma. Also provided is a novel method of iodinating the precursor compound.

  提供的是一种药物组合物，包括公式I的放射性碘化N-（2-（二乙氨基）乙基）-4-（4-氟苯甲酰胺）-5-碘-2-甲氧基苯甲酰胺。该药物组合物提供了一种稳定的配方，既可用于储存，也可用于治疗患有黑色素瘤的患者。此外，还提供了一种新的前体化合物碘化的方法。
• Radiohalogenated Benzamide Derivatives And Their Use In Tumor Diagnosis And Tumor Therapy
  申请人：FRIEBE Matthias

  公开号：US20110052492A1

  公开（公告）日：2011-03-03

  This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous properties, in particular with respect to tumor concentration and retardation, liver concentration and blood accumulation. The radiation-therapy doses to be achieved in the tumor, compared to healthy body tissue, are advantageous for the compounds according to the invention.

  本发明涉及新的放射性碘苯甲酰胺衍生物及其在肿瘤诊断和肿瘤治疗中的应用。本发明所述的放射性碘苯甲酰胺衍生物具有新颖且特别有利的性质，特别是在肿瘤浓度和缓慢代谢、肝脏浓度和血液积累方面。与健康组织相比，本发明的化合物在肿瘤中所需的放射治疗剂量具有优势。
• PHARMACEUTICAL COMPOSITION OF A RADIOIODINATED BENZAMIDE DERIVATIVE AND METHODS OF MAKING THE SAME
  申请人：Molecular Insight Pharmaceuticals, Inc.

  公开号：EP2328411A1

  公开（公告）日：2011-06-08
• [EN] PHARMACEUTICAL COMPOSITION OF A RADIOIODINATED BENZAMIDE DERIVATIVE AND METHODS OF MAKING THE SAME<br/>[FR] COMPOSITION PHARMACEUTIQUE À BASE D'UN DÉRIVÉ RADIOIODÉ D'UN BENZAMIDE ET SES PROCÉDÉS DE FABRICATION
  申请人：MOLECULAR INSIGHT PHARM INC

  公开号：WO2010028281A1

  公开（公告）日：2010-03-11

  Provided is a pharmaceutical composition comprising radioiodinated N-(2-(diethylamino)ethyl)-4-(4-fluorobenzamido)-5-iodo-2-methoxybenzamide of Formula I. The pharmaceutical composition provides a stable formulation for both storing and administering to patients having melanoma. Also provided is a novel method of iodinating the precursor compound.