1-(7-methyl-2-chlorothieno[3,2-d]pyrimidin-4-yl)-N³-(8-(2-diethylaminoethyl)-9-hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine | 1037800-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-(7-methyl-2-chlorothieno[3,2-d]pyrimidin-4-yl)-N³-(8-(2-diethylaminoethyl)-9-hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine
• 英文别名: 1-(7-methyl-2-chlorothieno[3,2-d] pyrimidin-4-yl)-N3-(8-(2-diethylaminoethyl)-9-hydroxy-6,7,8,9-tetrahydro-5H-benzo [7]annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine；3-[[5-amino-1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-1,2,4-triazol-3-yl]amino]-6-[2-(diethylamino)ethyl]-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ol
• CAS: 1037800-73-9
• 化学式: C₂₆H₃₃ClN₈OS
• 分子量: 541.12
• InChiKey: SOUGOLFJBNCSPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Substituted quinoline compounds
  申请人：Bertinato Peter

  公开号：US20050234099A1

  公开（公告）日：2005-10-20

  This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R 1 -R 7 , X 1 , m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.

  本发明涉及公式（I）中的MTP / Apo-B分泌抑制剂，其中R1-R7，X1，m和n如规范中所定义，以及包含该化合物的制药组合物，以及该化合物和组合物的使用方法。本发明的化合物在治疗肥胖和相关疾病，状况或障碍方面是有用的。
• SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS
  申请人：Goff Dane

  公开号：US20080188474A1

  公开（公告）日：2008-08-07

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  本发明揭示了替代三唑和含有该化合物的制药组合物，其在抑制受体蛋白酪氨酸激酶Axl的活性方面是有用的。还揭示了使用该化合物治疗与Axl活性相关的疾病或病况的方法。
• Triamide-substituted heterobicyclic compounds
  申请人：Bertinato Peter

  公开号：US20070093525A1

  公开（公告）日：2007-04-26

  This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R 1 -R 7 , X 1 , m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.

  本发明涉及公式(I)中的MTP / Apo-B分泌抑制剂，其中R1-R7，X1，m和n如说明书中所定义，以及包含该化合物的制药组合物，以及使用该化合物和组合物的方法。该发明的化合物对于治疗肥胖症及其相关疾病、病况或障碍具有用途。
• Substituted triazoles useful as AXL inhibitors
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2476679A2

  公开（公告）日：2012-07-18

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  所公开的取代三唑类化合物和含有这些化合物的药物组合物有助于抑制受体蛋白酪氨酸激酶 Axl 的活性。还公开了使用这些化合物治疗与 Axl 活性相关的疾病或病症的方法。
• Substituted triazoles useful as Axl inhibitors
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US10166216B2

  公开（公告）日：2019-01-01

  Substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.

  所公开的取代三唑类化合物和含有这些化合物的药物组合物有助于抑制受体蛋白酪氨酸激酶 Axl 的活性。还公开了使用这些化合物治疗与 Axl 活性相关的疾病或病症的方法。