磷酸二癸酯 | 7795-87-1

• 物质功能分类: 有机原料 - 无机酸酯
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 磷酸二癸酯
• 中文别名: 磷酸二正癸酯
• 英文名称: phosphoric acid didecyl ester
• 英文别名: di-n-decyl hydrogen phosphate；didecyl hydrogen phosphate；didecyl phosphate ester；Didecyl phosphate；phosphoric acid bis-decyl ester；Phosphorsaeure-didecylester
• CAS: 7795-87-1
• 化学式: C₂₀H₄₃O₄P
• mdl: MFCD00015062
• 分子量: 378.533
• InChiKey: QHAUASBJFFBWMY-UHFFFAOYSA-N

物化性质

• 熔点：
  47 °C
• 沸点：
  457.0±28.0 °C(Predicted)
• 密度：
  0.963±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2919900090
• 储存条件：
  室温

SDS

磷酸二癸酯

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模块 1. 化学品
产品名称： Didecyl Phosphate

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模块 2. 危险性概述
GHS分类
物理性危害 未分类
健康危害 未分类
环境危害 未分类
GHS标签元素
图标或危害标志 无
信号词 无信号词
危险描述 无
防范说明 无

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模块 3. 成分/组成信息
单一物质/混和物 单一物质
化学名(中文名)： 磷酸二癸酯
百分比： >95.0%(T)
CAS编码： 7795-87-1
俗名： Phosphoric Acid Didecyl Ester
分子式： C20H43O4P

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模块 4. 急救措施
吸入： 将受害者移到新鲜空气处，保持呼吸通畅，休息。若感不适请求医/就诊。
皮肤接触： 立即去除/脱掉所有被污染的衣物。用水清洗皮肤/淋浴。
若皮肤刺激或发生皮疹：求医/就诊。
眼睛接触： 用水小心清洗几分钟。如果方便，易操作，摘除隐形眼镜。继续清洗。
如果眼睛刺激：求医/就诊。
食入： 若感不适，求医/就诊。漱口。
紧急救助者的防护： 救援者需要穿戴个人防护用品，比如橡胶手套和气密性护目镜。

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模块 5. 消防措施
合适的灭火剂： 干粉，泡沫，雾状水，二氧化碳
特殊危险性： 小心，燃烧或高温下可能分解产生毒烟。
磷酸二癸酯

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模块 5. 消防措施
特定方法： 从上风处灭火，根据周围环境选择合适的灭火方法。
非相关人员应该撤离至安全地方。
周围一旦着火：如果安全，移去可移动容器。
消防员的特殊防护用具： 灭火时，一定要穿戴个人防护用品。

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模块 6. 泄漏应急处理
个人防护措施，防护用具， 使用个人防护用品。远离溢出物/泄露处并处在上风处。
紧急措施： 泄露区应该用安全带等圈起来，控制非相关人员进入。
环保措施： 防止进入下水道。
控制和清洗的方法和材料： 清扫收集粉尘，封入密闭容器。注意切勿分散。附着物或收集物应该立即根据合适的
法律法规处置。

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模块 7. 操作处置与储存
处理
技术措施： 在通风良好处进行处理。穿戴合适的防护用具。防止粉尘扩散。处理后彻底清洗双手
和脸。
注意事项： 如果粉尘或浮质产生，使用局部排气。
操作处置注意事项： 避免接触皮肤、眼睛和衣物。
贮存
储存条件： 保持容器密闭。存放于凉爽、阴暗处。
远离不相容的材料比如氧化剂存放。
包装材料： 依据法律。

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模块 8. 接触控制和个体防护
工程控制： 尽可能安装封闭体系或局部排风系统，操作人员切勿直接接触。同时安装淋浴器和洗
眼器。
个人防护用品
呼吸系统防护： 防尘面具。依据当地和政府法规。
手部防护： 防护手套。
眼睛防护： 安全防护镜。如果情况需要，佩戴面具。
皮肤和身体防护： 防护服。如果情况需要，穿戴防护靴。

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模块 9. 理化特性
固体
外形（20°C）：
外观： 晶体-粉末
颜色： 白色
气味： 无资料
pH: 无数据资料
熔点：
47°C
沸点/沸程 无资料
闪点： 无资料
爆炸特性
爆炸下限： 无资料
爆炸上限： 无资料
密度： 无资料
溶解度：
[水] 无资料
[其他溶剂] 无资料
磷酸二癸酯

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模块 10. 稳定性和反应性
化学稳定性： 一般情况下稳定。
危险反应的可能性： 未报道特殊反应性。
须避免接触的物质 氧化剂
危险的分解产物: 一氧化碳, 二氧化碳, 磷氧化物

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模块 11. 毒理学信息
急性毒性： 无资料
对皮肤腐蚀或刺激： 无资料
对眼睛严重损害或刺激： 无资料
生殖细胞变异原性： 无资料
致癌性：
IARC = 无资料
NTP = 无资料
生殖毒性： 无资料

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模块 12. 生态学信息
生态毒性：
鱼类： 无资料
甲壳类： 无资料
藻类： 无资料
残留性 / 降解性： 无资料
潜在生物累积 （BCF): 无资料
土壤中移动性
log水分配系数： 无资料
土壤吸收系数 （Koc）： 无资料
亨利定律 无资料
constant(PaM3/mol):

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模块 13. 废弃处置
如果可能，回收处理。请咨询当地管理部门。建议在可燃溶剂中溶解混合，在装有后燃和洗涤装置的化学焚烧炉中
焚烧。废弃处置时请遵守国家、地区和当地的所有法规。

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模块 14. 运输信息
联合国分类： 与联合国分类标准不一致
UN编号： 未列明

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模块 15. 法规信息
《危险化学品安全管理条例》（2002年1月26日国务院发布，2011年2月16日修订）: 针对危险化学品的安全使用、
生产、储存、运输、装卸等方面均作了相应的规定。
磷酸二癸酯

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模块16 - 其他信息
N/A

制备方法与用途

功能金属配合物的配体

反应信息

• 作为反应物：
  描述：

  磷酸二癸酯 在 calcium chloride 作用下， 生成 didecyl calcium phosphate
  参考文献：
  名称：

  一种制备二癸基磷酸钙的方法及其应用

  摘要：

  本发明提供了一种制备二癸基磷酸钙的方法，该方法包括以下步骤：1）癸醇和三氯氧磷在吡啶的存在下生成氧化磷酸二癸酯；其中，吡啶与三氯氧磷的体积比应为1:2）；2）氧化磷酸二癸酯再经水解酸化生成二癸基磷酸；3）然后二癸基磷酸与饱和CaCl2在40±2℃反应生成二癸基磷酸钙；其中，反应体系的溶剂为非质子极性溶剂。该磷酸酯类的钙盐制备方法简单，利于钙离子选择性电极的推广和应用。

  公开号：

  CN104109170B
• 作为产物：
  描述：

  癸醇 在 水 、 三乙胺 、 三氯氧磷 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 磷酸二癸酯
  参考文献：
  名称：

  长链磷酸二烷基酯的便捷制备：磷酸二烷基酯的合成

  摘要：

  摘要 氯氧化磷与伯醇（1.8当量）和三乙胺（1.8当量）在甲苯中反应，然后过滤并用蒸汽处理，得到的磷酸二烷基酯收率高，基本上没有磷酸三烷基酯的污染。 氯氧化磷与伯醇（1.8当量）和三乙胺（1.8当量）在甲苯中反应，然后过滤并用蒸汽处理，得到的磷酸二烷基酯收率高，基本上没有磷酸三烷基酯的污染。

  DOI：

  10.1055/s-0031-1290823

文献信息

• Synthetic Bilayer Membranes with Anionic Head Groups
  作者：Toyoki Kunitake、Yoshio Okahata

  DOI：10.1246/bcsj.51.1877

  日期：1978.6

  Anionic amphiphiles which possess two normal alkyl groups as the hydrophobic residue and sulfonate, phosphate or carboxylate groups as the hydrophilic residue were prepared. Most of these compounds aggregate extensively in water to form vesicles and lamellae which are probably formed by the molecular bilayer. These aggregates are quite similar to the lecithin liposome with respect to the restricted molecular motion and cholesterol binding.

  具有两个普通烷基作为疏水残基以及磺酸盐、磷酸盐或羧酸盐作为亲水残基的阴离子两性分子已被制备出来。这些化合物大多在水溶液中广泛聚集形成囊泡和片层结构，这些结构很可能由分子双层形成。这些凝聚体与卵磷脂脂质体在分子运动受限和胆固醇结合方面非常相似。
• Alkyl Chain Length Dependency in Hydrolysis of Liposomal Phosphatidylcholine by Dialkylphosphate.
  作者：Kimei HAYASHI、Kumi ARAKANE、Noboru NAITO、Tetsuo NAGANO、Masaaki HIROBE

  DOI：10.1248/cpb.43.1751

  日期：——

  Because an amphiphile with a positive or negative charge, shch as dialkylphosphate or stearylamine, is often added to liposomal phosphatidylcholine (PC) dispersions to prevent aggregation of the liposomes, we investigated the long-term stability of liposomes prepared from saturated PC in the presence of various amphiphiles. On storage of these liposomes at 40°C, PC was gradually hydrolyzed by dialkylphosphate, a negatively charged lipid, while neither stearylamine, a positively charged lipid, nor a non-charged lipid hydrolyzed PC at all. This hydrolysis of PC was examined using dialkylphosphates of various alkyl chain lengths (C10, C12, C14, C16, C18 and C20) and PC with different fatty acyl chain lengths (C14, C16 and C18). The rate of hydrolysis was maximum when the alkyl chain length of dialkylphosphate was almost equal to the fatty acyl chain length of PC. That is, the hydrolysis of dimyristoyl (C14) and dipalmitoyl (C16) acyl chains of PC was accelerated most by the incorporation of dimyristylphosphate (C14) and dipalmitylphosphate (C16), respectively. Distearoyl (C18) acyl chains of PC were hydrolyzed effectively by the incorporation of distearylphosphate (C18) as well as dipalmitylphosphate (C16). The hydrolysis did not occur when methyl dipalmitylphosphate was added instead of dipalmitylphosphate, or when the liposomal structure was decomposed by adding ethanol. These results suggest that dialkylphosphate and PC are aligned head to tail in liposomes and that the phosphate functional group causes the hydrolysis of the esters of PC.The incorporation of cholesterol into PC bilayers suppressed the hydrolysis of PC above the phase transition temperature (Tc) of PC, but increased it below the Tc. The hydrolysis of PC by dialkylphosphate appears to depend on membrane fluidity and to be accelerated with increased membrane fluidity, because cholesterol reduces the fluidity of the liposomal membrane above the Tc and enhances it below the Tc.

  因为经常在脂质体磷脂酰胆碱(PC)分散液中加入带正电或负电的两亲物质，如二烷基磷酸盐或硬脂胺，以防止脂质体聚集，所以我们研究了在存在各种两亲物质的情况下由饱和PC制备的脂质体的长期稳定性。在40°C下储存这些脂质体时，PC逐渐被带负电的脂质——二烷基磷酸盐水解，而带正电的脂质硬脂胺或不带电的脂质均不水解PC。通过使用具有不同烷基链长度的二烷基磷酸盐(C10, C12, C14, C16, C18和C20)和具有不同脂肪酸链长度的PC(C14, C16和C18)，研究了这种PC的水解作用。当二烷基磷酸盐的烷基链长度几乎等于PC的脂肪酸链长度时，水解速率达到最大。也就是说，PC的二肉豆蔻酰(C14)和二棕榈酰(C16)链的水解作用分别因加入二肉豆蔻基磷酸盐(C14)和二棕榈基磷酸盐(C16)而得到最大程度的加速。PC的二硬脂酰(C18)链也被加入的二硬脂基磷酸盐(C18)以及二棕榈基磷酸盐(C16)有效地水解。当加入甲基二棕榈基磷酸盐代替二棕榈基磷酸盐，或通过加入乙醇分解脂质体结构时，水解作用没有发生。这些结果表明，二烷基磷酸盐和PC在脂质体中以头对尾的方式排列，并且磷酸盐官能团导致PC的酯键水解。将胆固醇掺入PC双层膜中，在PC的相变温度(Tc)以上抑制了PC的水解，但在Tc以下增加了水解。PC被二烷基磷酸盐水解似乎取决于膜的流动性，并且随着膜流动性的增加而加速，因为胆固醇在Tc以上降低了脂质体膜的流动性，而在Tc以下增强了膜的流动性。
• Solvent-Free Microwave Synthesis of Trialkylphosphates
  作者：Laaldja Meddour-Boukhobza、Abdelhamid Elias、Mohamed Didi

  DOI：10.13005/ojc/300131

  日期：2014.3.30

  Trialkylphosphates are synthesized from alcohols by reaction with reactive phosphorus oxychloride under microwave irradiations and classical heating. Effects of these irradiations on the nature of the products and on the yield are studied.  The compounds were characterized by their spectroscopic data and elemental analysis. The obtained results show that the products of these reactions are essentially trialkylphosphates and alkylphosphoric acids.  They always show as the nature of the formed products and the yields in trialkylphosphates are comparable to those obtained in the classical conditions of heating. The speed of the reaction was increased by a factor from 40 to 120.

  在微波辐照和传统加热条件下，通过与活性氧氯化磷反应，从醇类合成三烷基磷酸盐。研究了这些辐照对产物性质和产量的影响。 通过光谱数据和元素分析对化合物进行了表征。研究结果表明，这些反应的产物主要是三烷基磷酸盐和烷基磷酸。 它们始终显示出所形成产物的性质，三烷基磷酸盐的产率与传统加热条件下获得的产率相当。反应速度从 40 倍提高到 120 倍。
• Synthesis of Alkyl Dihydrogenphosphate by the Reaction of Alcohols and Silyl Polyphosphate
  作者：Yoshiki Okamoto

  DOI：10.1246/bcsj.58.3393

  日期：1985.11

  Alkyl dihydrogenphosphates were readily prepared by phosphorylation of alcohols with trimethylsilyl polyphosphate or polyphosphorylated silica-gel.

  烷基二氢磷酸酯可通过与三甲基硅基多磷酸盐或多磷酸化硅胶对醇进行磷酸化而易于制备。
• Reactive monomer composition modified by a small-amount of lactones, an acrylic polyol resin, a curable resin composition, and a coating composition
  申请人：——

  公开号：US20040171867A1

  公开（公告）日：2004-09-02

  The present invention Nos. I and II relate to a hydroxyalkyl(meth)acrylate composition (a) modified by a small amount of lactones in which a proportion of monomers having two or more continuous chains (n≧2) of lactone is less than 50% (area % by GPC) which is obtained by a ring-opening polymerization of a lactone with a hydroxyalkyl(meth)acrylate, a method for the preparation thereof, and an acrylic polyol resin using thereof, 1 (in the formula, R, R 1 , R 2 , and R 3 are independently a hydrogen or a methyl group, “j” is an integer of 2-6, xn pieces of R 4 and R 5 are independently a hydrogen atom or an alkyl group having a carbon number of 1-12, “x” is 4-7, “n” is 0 or an integer of not less than 1, and an average value of “n” in the composition is not less than 0.3 to less than 1.0). By allowing to react the composition with other ethylenic unsaturated monomer and to formulate with a commonly-used crosslinking agent and other commonly-used components, there can be obtained a well-balanced high quality finishing agent for industries, an ultraviolet ray- or electron beam-curable coating agent, a composition which can be modified for a reactive improver, etc., and an acrylic polyol resin using thereof. The present invention No. III relates to a curable resin composition containing 0.5-80 parts by weight of an acrylic polyol resin (A) obtained using a hydroxyalkyl(meth)acrylate composition (a) modified by a small amount of lactones and 0.5-50 parts by weight of a melamine resin (B) [total of the (A) and (B) does not exceed, 100 parts by weight] as essential components. By the composition, even in a melamine-based curing system which is low in price, there can be obtained a curable-type coating composition in which an acid resistance is improved and highly well-balanced between an acid resistance and abrasion resistance, and which is also excellent in flexural resistance and adhesion in recoating. The present invention No. IV relates to a curable resin composition containing 0.5-80 parts by weight of an acrylic polyol resin (A) containing a hydroxyalkyl(meth)acrylate composition (a) modified by a small amount of lactones as a polymerizing component and 0.5-50 parts by weight of a melamine resin (B) [total of the (A) and (B) does not exceed 100 parts by weight] as essential components. By the composition, even in a melamine-based curing system which is low in price, there can be obtained a curable-type coating composition in which an acid resistance is improved and highly well-balanced between an acid resistance and abrasion resistance. The present invention No. V relates to a curable resin composition containing 0.5-80 parts by weight of an acrylic polyol resin (A) obtained using a hydroxyalkyl(meth)acrylate composition (a) modified by a small amount of lactones and 0.5-50 parts by weight of a polyisocyanate compound (B) [total of the (A) and (B) does not exceed 100 parts by weight] as essential components. By the composition, even in an isocyanate-based curing system, there can be obtained a curable-type coating composition in which a pot life is long and workability is improved, and which is highly well-balanced between an acid resistance and abrasion resistance, and which can provide a coating layer which is excellent also in flexural resistance and adhesion in recoating. The present invention No. VI relates to a curable resin composition containing 0.5-80 parts by weight of an acrylic polyol resin (A) obtained using a hydroxyalkyl(meth)acrylate composition (a) modified by a small amount of lactones and 0.5-50 parts by weight of a polyisocyanate compound (B) [total of the (A) and (B) does not exceed 100 parts by weight] as essential components. By the composition, even in an isocyanate-based curing system, there can be obtained a curable-type coating composition in which a pot life is long and workability is improved, and which is highly well-balanced between an acid resistance and abrasion resistance, and which can provide a coating layer which is excellent also in flexural resistance and adhesion in recoating. The present invention No. VII relates to a thermosetting resin composition containing 2-50 parts of an acrylic polyol resin obtained using a hydroxyalkyl(meth)acrylate composition (a) modified by a small amount of lactones and 30-80 parts of an acrylic copolymer having an alkoxysilyl group. By the composition, there can be obtained a thermosetting resin composition in which crosslinking density is elevated and hardness and abrasion resistance are improved as well as solving a problem of acid resistance and odor. The present invention No. VIII relates to a carboxylic group-contained acrylate composition (a′) modified by a small amount of lactones represented by a formula described below by allowing to react a hydroxyalkyl(meth)acrylate composition (a) modified by a small amount of lactones with a carboxylic anhydride, 2 (in the formula, R, R 1 , R 2 , and R 3 are independently a hydrogen or a methyl group, “j” is an integer of 2-6, xn pieces of R 4 and R 5 are independently a hydrogen atom or an alkyl group having a carbon number of 1-12, “x” is 4-7 , “n” is 0 or an integer of not less than 1, an average value of “n” in the composition is not less than 0.3 to less than 1.0 , R 6 is a residual group of a carboxylic acid, and “m” is an integer of 1-3), and relates to a method for the preparation thereof. By the method, there can be readily, efficiently, and economically obtained the carboxylic group-contained acrylate monomer composition modified by a small amount of lactones. The present invention No. IX relates to a curable resin composition containing 10-70 parts of an acrylic polycarboxylic resin essentially containing the carboxylic group-contained hydroxy(meth)acrylate monomer composition (a′) modified by a small amount of lactones as a polymerizing component and 0.5-80 parts of a polyepoxide. By the composition, there can be obtained a curable-type resin composition which can form a coating layer which is excellent in acid resistance, abrasion resistance, yellowing resistance, and outer appearance, and which is curable at a low temperature. The present invention No. X relates to a polyester unsaturated monomer (a″) modified by a small amount of lactones in which less than 1 mol of &egr;-caprolactone is allowed to react with 1 mol of a radically polymerizable unsaturated monomers containing carboxylic group under the presence of an acidic catalyst, and relates to a method for the preparation thereof. By the method, there can be readily and industrially prepared the monomer in a short step.

  本发明涉及一种由少量内酯修饰的羟基烷基（甲基）丙烯酸酯组合物（a），其中具有两个或多个连续链（n≥2）的内酯单体的比例小于50％（GPC的面积％），其通过羟基烷基（甲基）丙烯酸酯与内酯的开环聚合获得，以及制备方法和使用其的丙烯酸聚醇树脂。其中，在公共使用的交联剂和其他常用组分的反应下，可以获得工业上平衡良好的高质量涂料剂、紫外线或电子束固化涂料剂、可用于反应改进剂的组合物等。本发明还涉及含有0.5-80重量份羟基烷基（甲基）丙烯酸酯组合物（a）修饰的丙烯酸聚醇树脂（A）和0.5-50重量份三聚氰胺树脂（B）的可固化树脂组合物（A）和（B）的总重量不超过100重量份的可固化树脂组合物（III）。此外，还涉及含有0.5-80重量份羟基烷基（甲基）丙烯酸酯组合物（a）修饰的丙烯酸聚醇树脂（A）和0.5-50重量份聚异氰酸酯化合物（B）的可固化树脂组合物（A）和（B）的总重量不超过100重量份的可固化树脂组合物（V）和（VI）。还涉及含有羟基烷基（甲基）丙烯酸酯组合物（a）修饰的丙烯酸聚醇树脂（A）和具有烷氧基硅基团的丙烯酸共聚物的热固性树脂组合物（VII）。此外，还涉及通过使少量内酯与羟基烷基（甲基）丙烯酸酯组合物（a）在存在酸性催化剂的情况下反应而得到的含有羧基丙烯酸酯组合物（a′）的修饰物，以及含有羧基丙烯酸酯组合物（a′）和聚环氧化合物的可固化树脂组合物（IX）。最后，还涉及通过在存在酸性催化剂的情况下使少于1摩尔的ε-己内酯与含有羧基团的自由基聚合可的不饱和单体反应而得到的少量内酯修饰的聚酯不饱和单体（a″）以及其制备方法。