3-<2-Chlor-aethyl>-5-methyl-oxazolidin-2-on | 15055-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-<2-Chlor-aethyl>-5-methyl-oxazolidin-2-on
• 英文别名: 3-(2-Chlor-aethyl)-5-methyl-oxazolidin-2-on；3-(2-chloro-ethyl)-5-methyl-oxazolidin-2-one；3-(2-Chloroethyl)-5-methyl-1,3-oxazolidin-2-one
• CAS: 15055-42-2
• 化学式: C₆H₁₀ClNO₂
• mdl: MFCD19234117
• 分子量: 163.604
• InChiKey: HFQSSXINMUGOSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• N,N-BIS(2-DIALKYLPHOSPHINOETHYL)AMINE-BORANE COMPLEX AND PRODUCTION METHOD THEREFOR, AND METHOD FOR PRODUCING RUTHENIUM COMPLEX CONTAINING N,N-BIS(2-DIALKYLPHOSPHINOETHYL)AMINE AS LIGAND
  申请人：Takasago International Corporation

  公开号：US20190040090A1

  公开（公告）日：2019-02-07

  The purpose of the present invention is to provide an N,N-bis(2-dialkylphosphinoethyl)amine-borane complex which is a ruthenium complex that exhibits excellent catalytic activity in a hydrogenation reaction, etc., and a production method therefor, and a method for efficiently producing a ruthenium complex containing N,N-bis(2-dialkylphosphinoethyl)amine as a ligand. The present invention is capable of efficiently producing an amine-borane complex (3) by reacting an oxazolidinone compound (1) with a dialkylphosphine-borane compound (2) in the presence of a base. The present invention is also capable of efficiently producing a ruthenium complex (5) by reacting the amine-borane complex (3) with a ruthenium compound (4) in the presence of an amine. (In the formula, a solid line, a dashed line, B, C, H, L 1 -L 3 , LG, n, N, O, P, Ru, X, and R 1 -R 10 are as defined in the description.)

  本发明的目的是提供一种N,N-双(2-二烷基膦基乙基)胺硼烷配合物，它是一种在氢化反应中表现出优异催化活性的钌配合物等，以及其生产方法，以及一种有效生产含有N,N-双(2-二烷基膦基乙基)胺作为配体的钌配合物的方法。本发明能够通过在碱存在下将噁唑烷酮化合物(1)与二烷基膦硼烷化合物(2)反应来有效生产胺硼烷配合物(3)。本发明还能够通过在胺存在下将胺硼烷配合物(3)与钌化合物(4)反应来有效生产钌配合物(5)。
• Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
  申请人：Himmelsbach Frank

  公开号：US20060264450A1

  公开（公告）日：2006-11-23

  The present invention relates to bicyclic heterocycles of general formula wherein R a , R b , R c , R d , X and n are defined as in claim 1 , the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids which have valuable pharmacological properties, particularly an inhibiting effect on the signal transduction mediated by tyrosine kinases, their use in treating diseases, particularly tumoral diseases, as well as benign prostatic hyperplasia (BPH), diseases of the lungs and respiratory tract and the preparation thereof.

  本发明涉及一般式为的双环杂环化合物，其中Ra、Rb、Rc、Rd、X和n的定义如权利要求书中所述，其互变异构体、立体异构体、混合物及其盐，尤其是其与无机或有机酸的生理可接受盐，具有有价值的药理学特性，特别是对酪氨酸激酶介导的信号转导具有抑制作用，它们的用途在于治疗疾病，特别是肿瘤性疾病，以及良性前列腺增生症（BPH）、肺部和呼吸道疾病，以及其制备方法。
• N-N-bis(2-dialkylphosphinoethyl)amine-borane complex and production method therefor, and method for producing ruthenium complex containing N,N-bis(2-dialkylphosphinoethyl)amine as ligand
  申请人：Takasago International Corporation

  公开号：US10407448B2

  公开（公告）日：2019-09-10

  The purpose of the present invention is to provide an N,N-bis(2-dialkylphosphinoethyl)amine-borane complex which is a ruthenium complex that exhibits excellent catalytic activity in a hydrogenation reaction, etc., and a production method therefor, and a method for efficiently producing a ruthenium complex containing N,N-bis(2-dialkylphosphinoethyl)amine as a ligand. The present invention is capable of efficiently producing an amine-borane complex (3) by reacting an oxazolidinone compound (1) with a dialkylphosphine-borane compound (2) in the presence of a base. The present invention is also capable of efficiently producing a ruthenium complex (5) by reacting the amine-borane complex (3) with a ruthenium compound (4) in the presence of an amine. (In the formula, a solid line, a dashed line, B, C, H, L1-L3, LG, n, N, O, P, Ru, X, and R1-R10 are as defined in the description.)

  本发明的目的是提供一种N,N-双(2-二烷基膦乙基)胺硼烷络合物，它是一种在氢化反应等中表现出优异催化活性的钌络合物，并提供其生产方法，以及一种高效生产含有N,N-双(2-二烷基膦乙基)胺作为配体的钌络合物的方法。本发明能够通过在碱存在下使噁唑烷酮化合物（1）与二烷基膦硼烷化合物（2）反应，高效生产胺硼烷配合物（3）。本发明还能在胺存在的情况下，通过胺硼烷络合物（3）与钌化合物（4）反应，高效生产钌络合物（5）。 (式中，实线、虚线、B、C、H、L1-L3、LG、n、N、O、P、Ru、X 和 R1-R10 如说明中所定义）。
• US7196091B2
  申请人：——

  公开号：US7196091B2

  公开（公告）日：2007-03-27