5-trifluoromethyl-1-(3-trifluoromethyl-phenyl)-2(1H)-pyridinone | 1198411-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-trifluoromethyl-1-(3-trifluoromethyl-phenyl)-2(1H)-pyridinone
• 英文别名: 5-Trifluoromethyl-1-(3-trifluoromethyl-phenyl)-2(1H)-pyridinon；5-(Trifluoromethyl)-1-[3-(trifluoromethyl)phenyl]pyridin-2-one
• CAS: 1198411-42-5
• 化学式: C₁₃H₇F₆NO
• 分子量: 307.195
• InChiKey: LXVUXLRKIUDHAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
  申请人：Kossen Karl

  公开号：US20090318455A1

  公开（公告）日：2009-12-24

  Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

  公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物对p38 MAPK的抑制效力较低；并且其中接触是在SAPK调节浓度下进行的，该浓度对化合物抑制p38 MAPK的抑制浓度百分比较低。还公开了吡非尼酮的衍生物和类似物，它们可用于调节应激活化蛋白激酶（SAPK）系统。
• Substituted iminoazines
  申请人：——

  公开号：US20040029881A1

  公开（公告）日：2004-02-12

  The invention relates to novel substituted iminoazines of the general formula (I) 1 in which R 1 , R 2 , R 3 , R 4 , Z 1 , Z 2 and Z 3 are each as defined in the description, to a plurality of processes and intermediates for their preparation and to their use as herbicides.

  这项发明涉及一种新型的通式（I）中的取代亚胺嘧啶化合物，其中R1、R2、R3、R4、Z1、Z2和Z3分别如描述中所定义，以及它们的制备过程和中间体的多种方法，以及它们作为除草剂的用途。
• METHODS FOR TREATING ACUTE MYOCARDIAL INFARCTIONS AND ASSOCIATED DISORDERS
  申请人：Olgin Jeff

  公开号：US20100190731A1

  公开（公告）日：2010-07-29

  The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
• Methods for Treating Acute Myocardial Infarctions and Associated Disorders
  申请人：Olgin Jeff

  公开号：US20110218515A1

  公开（公告）日：2011-09-08

  The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
• METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS
  申请人：Kossen Karl

  公开号：US20120014917A1

  公开（公告）日：2012-01-19

  The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.