2H-benzopyrano[4,3-c]pyrazol-3-one | 918156-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2H-benzopyrano[4,3-c]pyrazol-3-one
• 英文别名: 2H-chromeno[4,3-c]pyrazol-3-one
• CAS: 918156-46-4
• 化学式: C₁₀H₆N₂O₂
• 分子量: 186.17
• InChiKey: DZEVUMSAIVIXGZ-UHFFFAOYSA-N

物化性质

• 熔点：
  227-229 °C(Solv: ethanol (64-17-5))
• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2H-benzopyrano[4,3-c]pyrazol-3-one 、 4-甲基氯苄 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 以97%的产率得到
  参考文献：
  名称：

  Insecticidal lead identification by screening benzopyrano[4,3-c] pyrazol-3(2H)-ones library constructed from multiple-parallel synthesis under microwave irradiation

  摘要：

  A rapid library-generation via liquid-phase multiple-parallel synthesis of 2-(substituted)benzyl-1-benzopyrano[4,3-c]pyrazol-3(2H)-ones, bearing two points of diversity, under microwave irradiation was successfully performed using chromenone-3-carboxylic acids as starting materials. Compared to an identical library generated by conventional parallel synthesis, microwave-assisted parallel synthesis dramatically decreased reaction times from an average of 16 h to 13 min, and the yields of products and intermediates were improved in most cases. A bioassay indicated that the compounds of the library exhibited excellent insecticidal activity against T. cinnabarinus at the dosage of 250 mg L-1, and some compounds still exhibited insecticidal activity when the dosage was reduced to 50 mg L-1. This shows that 2-(substituted) benzyl-1-benzopyrano[4,3-c]pyrazol-3(2H)-ones might be used as lead structures for further optimization. To our knowledge, this is the first report about the application of solution-phase multiple-parallel synthesis under microwave irradiation to construct libraries of benzopyrano-[4,3-c]pyrazol-3(2H)-ones with insecticidal activity. The coupling of microwave technology with liquid-phase parallel synthesis constitutes a novel and particularly attractive avenue for the rapid generation of structurally diverse libraries for lead discovery. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.08.020
• 作为产物：
  描述：

  色酮-3-甲酸 在 一水合肼 、 溶剂黄146 作用下， 反应 0.05h， 以85%的产率得到2H-benzopyrano[4,3-c]pyrazol-3-one
  参考文献：
  名称：

  Insecticidal lead identification by screening benzopyrano[4,3-c] pyrazol-3(2H)-ones library constructed from multiple-parallel synthesis under microwave irradiation

  摘要：

  A rapid library-generation via liquid-phase multiple-parallel synthesis of 2-(substituted)benzyl-1-benzopyrano[4,3-c]pyrazol-3(2H)-ones, bearing two points of diversity, under microwave irradiation was successfully performed using chromenone-3-carboxylic acids as starting materials. Compared to an identical library generated by conventional parallel synthesis, microwave-assisted parallel synthesis dramatically decreased reaction times from an average of 16 h to 13 min, and the yields of products and intermediates were improved in most cases. A bioassay indicated that the compounds of the library exhibited excellent insecticidal activity against T. cinnabarinus at the dosage of 250 mg L-1, and some compounds still exhibited insecticidal activity when the dosage was reduced to 50 mg L-1. This shows that 2-(substituted) benzyl-1-benzopyrano[4,3-c]pyrazol-3(2H)-ones might be used as lead structures for further optimization. To our knowledge, this is the first report about the application of solution-phase multiple-parallel synthesis under microwave irradiation to construct libraries of benzopyrano-[4,3-c]pyrazol-3(2H)-ones with insecticidal activity. The coupling of microwave technology with liquid-phase parallel synthesis constitutes a novel and particularly attractive avenue for the rapid generation of structurally diverse libraries for lead discovery. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.08.020

文献信息

• THERAPEUTIC AGENTS
  申请人：The Boots Company PLC

  公开号：EP0539372A1

  公开（公告）日：1993-05-05
• [EN] THERAPEUTIC AGENTS
  申请人：THE BOOTS COMPANY PLC

  公开号：WO1990001481A1

  公开（公告）日：1990-02-22

  (EN) This invention relates to compounds of formula (I), wherein R1 represents hydrogen or together with R2 represents a bond; R2 together with either one of R1 and R3 represents a bond; R3 together with either one of R2 and R4 represents a bond; R4 represents hydrogen or together with R3 represents a bond; R5 represents hydrogen or methyl; R6 represents hydrogen, halo, a C2-6 alkanoyl group, a C2-6 alkoxycarbonyl group, a C1-6 alkylthio group, a C1-6 alkylsulphinyl group, a C1-6 alkylsulphonyl group, carbamoyl, carboxy, or R5 and R6 together with the carbon atom to which they are attached represent a cyclopropyl group; R7 represents hydrogen, halo, trifluoromethyl, methoxy, a C1-6 alkyl group, a C1-6 alkylthio group or a C1-6 alkylsulphinyl group; R8 represents hydrogen, halo or trifluoromethyl; R9 and R10, which may be the same or different, each represent halo; or R9 represents hydrogen and R10 represents hydrogen, halo, trifluoromethyl, hydroxy, nitro, a C2-6 alkanoyloxy group, a C1-6 alkyl group or a C1-6 alkoxy group, which have immunomodulatory activity. Compositions containing these compounds and processes to make them are also disclosed.(FR) Cette invention concerne des composés de formule (I), dans laquelle R1 représente hydrogène ou représente avec R2 une liaison; R2 représente avec R1 ou R3 une liaison, R3 représente avec R2 ou R4 une liaison; R4 représente hydrogène ou représente avec R3 une liaison; R5 représente hydrogène ou méthyle; R6 représente hydrogène, halo, un groupe alcanoyle contenant 2 à 6 atomes de carbone, un groupe alkoxycarbonyle contenant 2 à 6 atomes de carbone, un groupe alkylthio contenant 1 à 6 atomes de carbone, un groupe alkylsulfinyle contenant 1 à 6 atomes de carbone, un groupe alkylsulfonyle contenant 1 à 6 atomes de carbone, carbamoyle, carboxy, ou R5 et R6 représentent avec l'atome de carbone auquel ils sont fixés un groupe cyclopropyle; R7 représente hydrogène, halo, trifluorométhyle, méthoxy, un groupe alkyle contenant 1 à 16 atomes de carbone, un groupe alkylthio contenant 1 à 6 atomes de carbone ou un groupe alkylsulfinyle contenant 1 à 6 atomes de carbone; R8 représente hydrogène, halo ou trifluorométhyle; R9 et R10, pouvant être identiques ou différents, représentent chacun halo; ou R9 représente hydrogène et R10 représente hydrogène, halo, trifluorométhyle, hydroxy, nitro, un groupe alcanoyloxy contenant 2 à 6 atomes de carbone, un groupe alkyle contenant 1 à 16 atomes de carbone ou un groupe alkoxy contenant 1 à 6 atomes de carbone, présentant une activité immunomodulatrice. Sont également décrites des compositions contenant ces composés ainsi que des procédés pour les fabriquer.
• Insecticidal lead identification by screening benzopyrano[4,3-c] pyrazol-3(2H)-ones library constructed from multiple-parallel synthesis under microwave irradiation
  作者：Zhong-Zheng Zhou、Guang-Fu Yang

  DOI：10.1016/j.bmc.2006.08.020

  日期：2006.12

  A rapid library-generation via liquid-phase multiple-parallel synthesis of 2-(substituted)benzyl-1-benzopyrano[4,3-c]pyrazol-3(2H)-ones, bearing two points of diversity, under microwave irradiation was successfully performed using chromenone-3-carboxylic acids as starting materials. Compared to an identical library generated by conventional parallel synthesis, microwave-assisted parallel synthesis dramatically decreased reaction times from an average of 16 h to 13 min, and the yields of products and intermediates were improved in most cases. A bioassay indicated that the compounds of the library exhibited excellent insecticidal activity against T. cinnabarinus at the dosage of 250 mg L-1, and some compounds still exhibited insecticidal activity when the dosage was reduced to 50 mg L-1. This shows that 2-(substituted) benzyl-1-benzopyrano[4,3-c]pyrazol-3(2H)-ones might be used as lead structures for further optimization. To our knowledge, this is the first report about the application of solution-phase multiple-parallel synthesis under microwave irradiation to construct libraries of benzopyrano-[4,3-c]pyrazol-3(2H)-ones with insecticidal activity. The coupling of microwave technology with liquid-phase parallel synthesis constitutes a novel and particularly attractive avenue for the rapid generation of structurally diverse libraries for lead discovery. (c) 2006 Elsevier Ltd. All rights reserved.