Azido-PEG1-CH2CO2-NHS | 1480545-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Azido-PEG1-CH2CO2-NHS
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 2-(2-azidoethoxy)acetate
• CAS: 1480545-09-2
• 化学式: C₈H₁₀N₄O₅
• 分子量: 242.191
• InChiKey: KYDOCGOPXOETIG-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于DMSO、DCM、DMF

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  87.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Azido-PEG1-CH2CO2-NHS 、 巴龙霉素 以 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of Multifunctional PAMAM–Aminoglycoside Conjugates with Enhanced Transfection Efficiency

  摘要：

  The development of multifunctional vectors for efficient and safe gene delivery is one of the major challenges for scientists working in the gene therapy field. In this context, we have designed a novel type of aminoglycoside-rich dendrimers with a defined structure based on polyamidoamine (PAMAM) in order to develop efficient, nontoxic gene delivery vehicles. Three different conjugates, i.e., PAMAM G4-neamine, -paromomycin, and -neomycin, were synthesized and characterized by nuclear magnetic resonance (NMR) and MALDI analysis. The conjugates were found to self-assemble electrostatically with plasmid DNA, and unlike neamine conjugate, each at its optimum showed increased gene delivery potency compared to PAMAM G4 dendrimer in three different cell lines, along with negligible cytotoxicity. These results all disclosed aminoglycosides as suitable functionalities for tailoring safe and efficient multifunctional gene delivery vectors.

  DOI：

  10.1021/bc4003635