1-(4-methoxyphenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-5-pyrazolone | 60798-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-methoxyphenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-5-pyrazolone
• 英文别名: 1,3-Di(p-methoxyphenylen)-pyrazolon-(5)；2,5-bis-(4-methoxy-phenyl)-1,2-dihydro-pyrazol-3-one；2,5-bis(4-methoxyphenyl)-4H-pyrazol-3-one
• CAS: 60798-15-4
• 化学式: C₁₇H₁₆N₂O₃
• 分子量: 296.326
• InChiKey: ZUPVYTBXYNQXQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• EP3766544A1
  申请人：——

  公开号：EP3766544A1

  公开（公告）日：2021-01-20
• [EN] NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRAZOLONE EN TANT QU'INHIBITEURS D'INTERACTION PD-1/PD-L1
  申请人：CENTRE HOSPITALIER REGIONAL UNIV LILLE

  公开号：WO2021009384A1

  公开（公告）日：2021-01-21

  The present invention relates to novel pyrazolone derivatives of the following formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof and to a pharmaceutical composition comprising thereof. The present invention also concerns the use of compound of formula (I) or the pharmaceutical composition comprising said compound as a drug, notably in the prevention and/or treatment of PD-L1-PD-1 interactions-related diseases, such as cancer, neurological diseases and chronic infections. The present invention also relates to a method for the preparation of a compound of formula (I).