4-马来酰亚胺基甲基苯甲酸(N-羟基琥珀酰亚胺)酯 | 64987-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-马来酰亚胺基甲基苯甲酸(N-羟基琥珀酰亚胺)酯
• 英文名称: 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-ylmethyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester
• 英文别名: 4-(2-N-Maleimido)methyl benzoic acid-NHS；(2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]benzoate
• CAS: 64987-84-4
• 化学式: C₁₆H₁₂N₂O₆
• 分子量: 328.281
• InChiKey: REEZZJQIDFJMAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  540.4±60.0 °C(Predicted)
• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Process for preparing urokinase complex
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0109653A2

  公开（公告）日：1984-05-30

  This invention provides a process for preparing a fibrin-adsorable protein-urokinase complex characterized by reacting a protein adsorbable by fibrin with urokinase in the presence of a protein coupling reagent represented by the formula wherein R is phenylene or cycloalkylene, A is lower alkylene, B is lower alkylene which may optionally be substituted by lower alkylthio or phenyl-lower alkylthio, and ℓ, m and n are each 0 or 1 provided that ℓ, m and n are not 0 at the same time. The complex is useful as a thrombolytic agent.

  本发明提供了一种制备纤维蛋白-可吸附蛋白质-尿激酶复合物的工艺，其特征在于在由式 所表示的蛋白质偶联试剂存在下，使可被纤维蛋白吸附的蛋白质与尿激酶反应。 其中 R 是亚苯基或环烷基，A 是低级亚烷基，B 是可被低级烷硫基或苯基-低级烷硫基取代的低级亚烷基，ℓ、m 和 n 各为 0 或 1，但 ℓ、m 和 n 不能同时为 0。 该复合物可用作血栓溶解剂。
• Standard materials for measurement of immune complexes and method for measurement of immune complexes
  申请人：TEIJIN LIMITED

  公开号：EP0155141A2

  公开（公告）日：1985-09-18

  A standard material for measuring immune complexes which is prepared by chemically binding immunoglobulin and/or its fragment with a complement and/or its derivative through the medium of a bifunctional reagent. By using the standard material, the standard curve which is used for measuring immune comples existing in the blood is obtained.

  一种用于测量免疫复合物的标准物质，其制备方法是通过双功能试剂将免疫球蛋白和/或其片段与补体和/或其衍生物进行化学结合。通过使用该标准物质，可获得用于测量血液中存在的免疫复合物的标准曲线。
• ANTI-ENDOSERINE ANTIBODY
  申请人：Yamasa Shoyu Kabushiki Kaisha

  公开号：EP0423333A1

  公开（公告）日：1991-04-24

  An antibody specifically reacting with endoserine, a process for its preparation, an immunological assay of endoserine using said antibody as an antibody reagent, and a kit for the assay are disclosed.

  本发明公开了一种能与内丝氨酸发生特异性反应的抗体、其制备方法、使用所述抗体作为抗体试剂对内丝氨酸进行免疫学检测的方法以及用于检测的试剂盒。
• BIOSENSOR AND MANUFACTURING METHOD OF BIOSENSOR
  申请人：ARKRAY, Inc.

  公开号：EP3156790A1

  公开（公告）日：2017-04-19

  A biosensor includes a plurality of electrodes including a working electrode, and a detection layer containing an enzyme for exchanging electrons with the working electrode, a crosslinking agent and an electrically conductive polymer and having a contact area with the working electrode defined by a predetermined area.

  一种生物传感器包括多个电极，其中包括一个工作电极和一个检测层，检测层含有一种用于与工作电极交换电子的酶、一种交联剂和一种导电聚合物，检测层与工作电极的接触区域由一个预定区域限定。
• BIOSENSOR
  申请人：ARKRAY, Inc.

  公开号：EP3156789A1

  公开（公告）日：2017-04-19

  A biosensor includes a plurality of electrodes including a working electrode, and a detection layer which is immobilized on the working electrode and contains a crosslinking agent, an electrically conductive macromolecule and an enzyme transferring and receiving electrons to and from the working electrode. The working electrode is in an open system.

  一种生物传感器包括多个电极，其中包括一个工作电极，以及一个固定在工作电极上的检测层，该检测层含有交联剂、导电大分子和酶，可将电子传递到工作电极或从工作电极接收电子。工作电极处于开放系统中。