2-[4-(4-methyl-piperazin-1-yl)-phenyl]-1H-pyrrolo[2,3-f]isoquinoline | 1031440-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-(4-methyl-piperazin-1-yl)-phenyl]-1H-pyrrolo[2,3-f]isoquinoline
• 英文别名: 2-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrrolo[2,3-f]isoquinoline
• CAS: 1031440-55-7
• 化学式: C₂₂H₂₂N₄
• 分子量: 342.443
• InChiKey: BYDQFULTIXTWOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 2-(4-bromo-phenyl)-1H-pyrrolo[2,3-f]isoquinoline 在 palladium diacetate sodium t-butanolate 、 2-(二环己基膦基)联苯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以79%的产率得到2-[4-(4-methyl-piperazin-1-yl)-phenyl]-1H-pyrrolo[2,3-f]isoquinoline
  参考文献：
  名称：

  WO2008/65054

  摘要：

  公开号：

文献信息

• TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES
  申请人：Vanotti Ermes

  公开号：US20100075998A1

  公开（公告）日：2010-03-25

  The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine, means either simple or double carbon-carbon bond and R 1 , R 2 and R 3 are as defined in the specification. Further objects of the invention are a process for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Cdc7 and AKT kinase activity, like cancer.

  本发明提供了三环吲哚和（4,5-二氢）吲哚的公式（I）或其药学上可接受的盐：其中环A代表融合的吡唑、吡啶或嘧啶，表示单重或双重碳-碳键，R1、R2和R3如规范中所定义。本发明的进一步目标是公式（I）化合物的制备方法，包含它们的制药组合物以及治疗细胞增殖性疾病的方法。事实上，公式（I）化合物在治疗与失调的蛋白激酶活性有关的疾病，特别是Cdc7和AKT激酶活性，如癌症方面非常有用。
• Tricyclic indoles and (4,5-dihydro) indoles
  申请人：Nerviano Medical Sciences S.R.L.

  公开号：US08207180B2

  公开（公告）日：2012-06-26

  The present invention provides tricyclic indoles and (4,5-dihydro) indoles of the formula (I) or a pharmaceutically acceptable salt thereof: wherein the ring A represents a fused pyrazole, pyridine or pyrimidine, means either simple or double carbon-carbon bond and R1, R2 and R3 are as defined in the specification. Further objects of the invention are a process for the preparation of the compounds of the formula (I), pharmaceutical compositions comprising them and methods for treating cell proliferative disorders. As a matter of fact, the compounds of the formula (I) are useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, in particular Cdc7 and AKT kinase activity, like cancer.

  本发明提供了式(I)或其药学上可接受的盐的三环吲哚和(4,5-二氢)吲哚，其中环A代表融合的吡唑、吡啶或嘧啶，表示单一或双重碳-碳键，而R1、R2和R3如规范中所定义。本发明的进一步目的是提供式(I)化合物的制备方法、包含它们的制药组合物以及治疗细胞增殖障碍的方法。事实上，式(I)化合物在治疗与蛋白激酶活性失调有关的疾病，特别是Cdc7和AKT激酶活性，如癌症方面是有用的。
• US8207180B2
  申请人：——

  公开号：US8207180B2

  公开（公告）日：2012-06-26