3-Pyridinesulfonamide, N-[(methylamino)carbonyl] | 121822-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Pyridinesulfonamide, N-[(methylamino)carbonyl]
• 英文别名: 1-methyl-3-pyridin-3-ylsulfonylurea
• CAS: 121822-79-5
• 化学式: C₇H₉N₃O₃S
• 分子量: 215.23
• InChiKey: IMKXHOZAZHUQCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  96.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Isoxazole Derivatives as FXR Agonists and Methods of Use Thereof
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US20170333399A1

  公开（公告）日：2017-11-23

  The present invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR and methods for their preparation and use.